Solutions for managing variability in non-invasive brain stimulation studies
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Solutions for managing variability in non-invasive brain stimulation studiesData
2020-02-06Cita bibliográfica
Guerra, A., López-Alonso, V., Cheeran, B., Suppa, A. (2020). Solutions for managing variability in non-invasive brain stimulation studies. Neuroscience Letters, 719:133332.
Resumo
[Abstract] Introduction: In the last three decades, a number of non-invasive brain stimulation (NIBS) protocols, capable of assessing and
modulating plasticity in the human motor cortex (M1), have been described. For almost as long, NIBS has
delivered the tantalising prospect of non-invasive neuromodulation as a therapeutic intervention for neurorehabilitation,
psychiatry, chronic pain and other disease states. Apart from modest effects in depression, this
early promise has not been realised since the symptomatic improvements produced by NIBS are generally weak.
One key factor explaining this lack of clinical translation concerns variability in response to NIBS. Several studies
have demonstrated a number of physiological, technical and statistical factors accounting for intra- and intersubject
variability. However, solutions to overcome this problem are still under debate. In the present review, we
have provided a detailed description of methodological and technical solutions to control known factors influencing
variability. We have also suggested potential strategies to strengthen and stabilize NIBS-induced aftereffects.
Finally, we propose new possible outcome variables which better reflect intrinsic cortical activity, allowing
a more sensitive measurement and valid interpretation of responses to NIBS.
Palabras chave
Non-invasive brain stimulation
Transcranial magnetic stimulation
Theta burst stimulation
Paired associative stimulation
Transcranial direct current stimulation
Variability
Transcranial magnetic stimulation
Theta burst stimulation
Paired associative stimulation
Transcranial direct current stimulation
Variability
Versión do editor
Dereitos
© Elsevier
ISSN
0304-3940
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