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Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation

dc.contributor.authorGaudêncio, Susana P.
dc.contributor.authorBayram, Engin
dc.contributor.authorLukić Bilela, Lada
dc.contributor.authorCueto, Mercedes
dc.contributor.authorDíaz-Marrero, Ana R.
dc.contributor.authorHaznedaroglu, Berat Zeki
dc.contributor.authorJiménez, Carlos
dc.contributor.authorMandalakis, Manolis
dc.contributor.authorPereira, Florbela
dc.contributor.authorReyes, Fernando
dc.contributor.authorTasdemir, Deniz
dc.date.accessioned2023-10-25T15:14:42Z
dc.date.available2023-10-25T15:14:42Z
dc.date.issued2023-05-19
dc.identifier.citationGaudêncio, S.P.; Bayram, E.; Lukić Bilela, L.; Cueto, M.; Díaz-Marrero, A.R.; Haznedaroglu, B.Z.; Jimenez, C.; Mandalakis, M.; Pereira, F.; Reyes, F.; et al. Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation. Mar. Drugs 2023, 21, 308. https://doi.org/10.3390/md21050308es_ES
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/2183/33919
dc.descriptionThis article belongs to the Collection Ocean4Bioteches_ES
dc.description.abstract[Abstract] Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particularly the determination of the absolute configuration of metabolites with stereogenic centers. This review comprehensively focuses on recent technological and instrumental advances, highlighting the development of methods that alleviate these obstacles, paving the way for accelerating NP discovery towards biotechnological applications. Herein, we emphasize the most innovative high-throughput tools and methods for advancing bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.es_ES
dc.description.sponsorshipThis publication is based upon work from COST Action CA18238 (Ocean4Biotech), funded by the European Cooperation in Science and Technology (COST) Program in the period 2019–2023. SPG: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the projects UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. LLB: The publication is part of a project that has received funding from the Erasmus + Project No. ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP; GA.2019-1991/001-001. Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans HEIs/ECOBIAS. CJ: This work was supported by grants PID2021-122732OB-C22 from MCIN/AEI/10.13039/501100011033/FEDER “A way to make Europe” (AEI, Spanish State Agency for Research and FEDER Programme from the European Union) and RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, co-funded by the FEDER Programme from the European Union, and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). FP: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDB/50006/2020 of the Research Unit on Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) and for an Assistant Research Position (CEECIND/01649/2021). MC: INTERREG-MAC2/1.1b/279 (AHIDAGRO) and the Ministerio de Ciencia e Innovación (Spain) (grant PID2020-115979RR-C32). ARDM is supported with funds from Proyecto Intramural Especial CSIC [Ref. 202280I032]es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; UIDP/04378/2020es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; UIDB/04378/2020es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; LA/P/0140/2020es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; UIDB/50006/2020es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; CEECIND/01649/2021es_ES
dc.description.sponsorshipConsejo Superior de Investigaciones Científicas; 202280I032es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021 -2023/PID2021-122732OB-C22/ES/PAPEL DE LOS SIDEROFOROS EN EL DESARROLLO DE INFECCIONES BACTERIANAS EN MOLUSCOS BIVALVOS: APLICACIONES PARA LA MEJORA DEL CULTIVO DE ALMEJA (SUBPROYECTO 2)es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093634-B-C22/ES/FACTORES DE VIRULENCIA BACTERIANOS COMO DIANAS TERAPEUTICAS EN PECES: CARACTERIZACION DE SIDEROFOROS Y DESARROLLO DE NUEVOS TRATAMIENTOS CONTRA FORUNCULOSIS Y TENACIBACULOSIS/es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115979RR-C32/ES/BACTERIAS MARINAS PARA MEJORAR LA CALIDAD Y LA SEGURIDAD ALIMENTARIA/es_ES
dc.relation.urihttps://doi.org/10.3390/md21050308es_ES
dc.rightsAtribución 4.0 Internacionales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBlue biotechnologyes_ES
dc.subjectNatural productses_ES
dc.subjectHigh-Throughput Screening (HTS)es_ES
dc.subjectMode of Action (MoA)es_ES
dc.subjectMolecular networkinges_ES
dc.subjectDereplicationes_ES
dc.subjectNatural products databaseses_ES
dc.subjectGlobal Natural Product Social Molecular Networking (GNPS)es_ES
dc.subjectInformatic chemometricses_ES
dc.subjectHigh Throughput Next-Generation Sequencing (HT/NGS)es_ES
dc.subjectComputer Assisted Structure Elucidation (CASE)es_ES
dc.subjectRelative and absolute configuration determination in structure elucidationes_ES
dc.titleAdvanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleMarine Drugses_ES
UDC.volume21es_ES
UDC.issue5es_ES
UDC.endPage308es_ES
dc.identifier.doi10.3390/md21050308


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