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Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction
dc.contributor.author | Fernández, Rosa | |
dc.contributor.author | Guillamón, Antonio | |
dc.contributor.author | Cortés-Cortés, Joselyn | |
dc.contributor.author | Gómez-Gil, Esther | |
dc.contributor.author | Jácome, M. A. | |
dc.contributor.author | Esteva, Isabel | |
dc.contributor.author | Almaraz, Mari Cruz | |
dc.contributor.author | Mora, Mireia | |
dc.contributor.author | Aranda, Gloria | |
dc.contributor.author | Pásaro, Eduardo | |
dc.date.accessioned | 2023-10-11T12:48:02Z | |
dc.date.available | 2023-10-11T12:48:02Z | |
dc.date.issued | 2018-08-27 | |
dc.identifier.citation | Fernández, R., Guillamon, A., Cortés-Cortés, J., Gómez-Gil, E., Jácome, A., Esteva, I., Almaraz, M., Mora, M., Aranda, G., Pásaro, E., 2018. Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction. Psychoneuroendocrinology 98, 161–167. https://doi.org/10.1016/j.psyneuen.2018.07.032 | es_ES |
dc.identifier.issn | 1873-3360 | |
dc.identifier.issn | 0306-4530 | |
dc.identifier.uri | http://hdl.handle.net/2183/33724 | |
dc.description.abstract | [Abstract] Background: Polymorphisms in sex steroid receptors have been associated with transsexualism. However, published replication studies have yielded inconsistent findings, possibly because of a limited sample size and/or the heterogeneity of the transsexual population with respect to the onset of dysphoria and sexual orientation. We assessed the role of androgen receptor (AR), estrogen receptors alpha (ERα) and beta (ERβ), and aromatase (CYP19A1) in two large and homogeneous transsexual male-to-female (MtF) and female-to-male (FtM) populations. Methods: The association of each polymorphism with transsexualism was studied with a twofold subject-control analysis: in a homogeneous population of 549 early onset androphilic MtF transsexuals versus 728 male controls, and 425 gynephilic FtMs versus 599 female controls. Associations and interactions were investigated using binary logistic regression. Results: Our data show that specific allele and genotype combinations of ERβ, ERα and AR are implicated in the genetic basis of transsexualism, and that MtF gender development requires AR, which must be accompanied by ERβ. An inverse allele interaction between ERβ and AR is characteristic of the MtF population: when either of these polymorphisms is short, the other is long. ERβ and ERα are also associated with transsexualism in the FtM population although there was no interaction between the polymorphisms. Our data show that ERβ plays a key role in the typical brain differentiation of humans. Conclusion: ERβ plays a key role in human gender differentiation in males and females. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministry of Science and Innovation [PSI2014 - 58004-P (AG)] and the Xunta de Galicia [grant number ED431B 2016/013 (EP)]. J. Cortés-Cortés was supported by a doctoral fellowship FPU 15/02558 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431B 2016/013 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2014-58004-P/ES/LAS REDES CEREBRALES EN PERSONAS TRANSSEXUALES: UN ESTUDIO DE NEUROIMAGEN FUNCIONAL, METABOLOMICO Y GENETICO SOBRE LA ETIOLOGIA DE LA TRANSEXUALIDAD Y LA IDENTIDAD DE GENERO | es_ES |
dc.relation | info:eu-repo/grantAgreement/MECD/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FPU15%2F02558/ES/ | |
dc.relation.uri | https://doi.org/10.1016/j.psyneuen.2018.07.032 | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Androgen receptor | es_ES |
dc.subject | Aromatase | es_ES |
dc.subject | Estrogen receptor | es_ES |
dc.subject | Female-to-male transsexuals | es_ES |
dc.subject | Gender dysphoria | es_ES |
dc.subject | Male-to-female transsexuals | es_ES |
dc.title | Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Psychoneuroendocrinology | es_ES |
UDC.volume | 98 | es_ES |
UDC.startPage | 161 | es_ES |
UDC.endPage | 167 | es_ES |
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