Mostrar o rexistro simple do ítem
DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se
dc.contributor.author | Nicoletti, C. F. | |
dc.contributor.author | Pinhel, M.A.S. | |
dc.contributor.author | Díaz-Lagares, Angel | |
dc.contributor.author | Casanueva, F. | |
dc.contributor.author | Jácome, M. A. | |
dc.contributor.author | Pinhanelli, Vitor Caressato | |
dc.contributor.author | De Oliveira, B.A. | |
dc.contributor.author | Crujeiras, A. B. | |
dc.contributor.author | Nonino, C. B. | |
dc.date.accessioned | 2023-10-11T11:29:06Z | |
dc.date.available | 2023-10-11T11:29:06Z | |
dc.date.issued | 2019-05-27 | |
dc.identifier.citation | Nicoletti, C.F., Pinhel, M.A.S., Diaz-Lagares, A. et al. DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se. BMC Med Genomics 12, 72 (2019). https://doi.org/10.1186/s12920-019-0522-7 | es_ES |
dc.identifier.issn | 1755-8794 | |
dc.identifier.uri | http://hdl.handle.net/2183/33723 | |
dc.description.abstract | [Abstract] Background/objectives: Obesity has been associated with gene methylation regulation. Recent studies have shown that epigenetic signature plays a role in metabolic homeostasis after Roux-en Y gastric bypass (RYGB). To conduct a genome-wide epigenetic analysis in peripheral blood to investigate whether epigenetic changes following RYGB stem from weight loss or the surgical procedure per se. Subjects/methods: By means of the Infinium Human Methylation 450 BeadChip array, global methylation was analyzed in blood of 24 severely obese women before and 6 months after RYGB and in 24 normal-weight women (controls). Results: In blood cells, nine DMCpG sites showed low methylation levels before surgery, methylation levels increased after RYGB and neared the levels measured in the controls. Additionally, 44 CpG sites associated with the Wnt and p53 signaling pathways were always differently methylated in the severely obese patients as compared to the controls and were not influenced by RYGB. Finally, 1638 CpG sites related to inflammation, angiogenesis, and apoptosis presented distinct methylation in the post-surgery patients as compared to the controls. Conclusion: Bariatric surgery per se acts on CpGs related to inflammation, angiogenesis, and endothelin-signaling. However, the gene cluster associated with obesity remains unchanged, suggesting that weight loss 6 months after RYGB surgery cannot promote this effect. | es_ES |
dc.description.sponsorship | This study’s data collection, DNA and statistical analysis was supported by São Paulo Research Foundation (FAPESP) (grants #2017/07220–7, #2016/05638–1 and #2015/18669–0). Also, statistical and bioinformatics analysis was supported by “Centro de Investigacion Biomedica En Red” (CIBERobn) and grants (PI17/01287) from the “Instituto de Salud Carlos III” (ISCIII), Spain, co-financed by the European Regional Development Fund (FEDER), MINECO grants MTM2014–52876-R and MTM2017–82724-R, and by the Xunta de Galicia (Grupos de Referencia Competitiva ED431C-2016-015 and Centro Singular de Investigación de Galicia ED431G/01), all of them through the ERDF. A Diaz-Lagares is funded by a research contract “Juan Rodés” (JR17/00016) and Ana B Crujeiras is funded by a research contract “Miguel Servet” (CP17/00088) from the ISCIII, co-financed by the European Regional Development Fund (FEDER) | es_ES |
dc.description.sponsorship | Brasil. Fundação de Amparo à Pesquisa do Estado de São Paulo; #2017/07220–7 | es_ES |
dc.description.sponsorship | Brasil. Fundação de Amparo à Pesquisa do Estado de São Paulo; #2016/05638–1 | es_ES |
dc.description.sponsorship | Brasil. Fundação de Amparo à Pesquisa do Estado de São Paulo; #2015/18669–0 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C-2016-015 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G/01 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01287/ES/IDENTIFICACION DE BIOMARCADORES EPIGENEOMICOS DE OBESIDAD INDICATIVOS DE SUSCEPTIBILIDAD A DIFERENTES TRATAMIENTOS Y RE-GANANCIA DE PESO CORPORAL | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2014-52876-R/ES/INFERENCIA ESTADISTICA COMPLEJA Y DE ALTA DIMENSION: EN GENOMICA, NEUROCIENCIA, ONCOLOGIA, MATERIALES COMPLEJOS, MALHERBOLOGIA, MEDIO AMBIENTE, ENERGIA Y APLICACIONES INDUSTRI | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2017-82724-R/ES/INFERENCIA ESTADISTICA FLEXIBLE PARA DATOS COMPLEJOS DE GRAN VOLUMEN Y DE ALTA DIMENSION | es_ES |
dc.relation.uri | https://doi.org/10.1186/s12920-019-0522-7 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Obesity | es_ES |
dc.subject | Bariatric surgery | es_ES |
dc.subject | Epigenetics | es_ES |
dc.subject | DNA methylation | es_ES |
dc.subject | Pathway | es_ES |
dc.subject | Weight loss | es_ES |
dc.title | DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | BMC Medical Genomics | es_ES |
UDC.volume | 12 | es_ES |
UDC.startPage | 72 | es_ES |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-MODES - Artigos [141]