CB[7]- and CB[8]-Based [2]-(Pseudo)rotaxanes with Triphenylphosphonium-Capped Threads: Serendipitous Discovery of a New High-Affinity Binding Motif
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CB[7]- and CB[8]-Based [2]-(Pseudo)rotaxanes with Triphenylphosphonium-Capped Threads: Serendipitous Discovery of a New High-Affinity Binding MotifData
2022-05-06Cita bibliográfica
Neira, I.; Peinador, C.; García, M. D. CB[7]- and CB[8]-Based [2]-(Pseudo)Rotaxanes with Triphenylphosphonium-Capped Threads: Serendipitous Discovery of a New High-Affinity Binding Motif. Org. Lett. 2022, 24 (25), 4491–4495. https://doi.org/10.1021/acs.orglett.2c01028
Resumo
[Abstract] The synthesis of new triphenylphosphonium-capped cucurbit[7]uril (CB[7])- and cucurbit[8]uril (CB[8])-based [2]rotaxanes was achieved by a simultaneous threading-capping strategy. While the use of CB[7] produced the designed [2]rotaxane, attempts to obtain the CB[8] analogue were unsuccessful due to the unexpected strong interaction found between the host and the phosphonium caps leading to pseudo-heteroternary host–guest complexes. This unusual binding motif has been extensively studied experimentally, with results in good agreement with those obtained by dispersion-corrected DFT methods.
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Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG
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Atribución 4.0 Internacional
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1523-7060
1523-7052
1523-7052