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Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma
dc.contributor.author | López-López, Daniel | |
dc.contributor.author | Trevissón Redondo, Bibiana | |
dc.contributor.author | Becerro-de-Bengoa-Vallejo, Ricardo | |
dc.contributor.author | Sevillano Fernández, David | |
dc.contributor.author | González Hidalgo, Natalia | |
dc.contributor.author | Losa Iglesias, Marta Elena | |
dc.contributor.author | Alou, Luis | |
dc.date.accessioned | 2022-05-04T08:07:33Z | |
dc.date.available | 2022-05-04T08:07:33Z | |
dc.date.issued | 2022-03 | |
dc.identifier.citation | Trevissón, B.; Becerro-de-Bengoa-Vallejo, R.; Sevillano, D.; González, N.; Losa-Iglesias, M.E.; López-López, D.; Alou, L. Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma. J. Clin. Med. 2022, 11, 1683. https://doi.org/10.3390/jcm11061683 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/30589 | |
dc.description.abstract | [Abstract] Few studies have checked the impact of the hormonal/immunological dimorphism of patients on the cellular composition of platelet-rich plasma products (PRP). Whole blood (WB) from 26 volunteers was concentrated using a device previously characterized. Platelet and white blood cell (WBC) counts in WB and PRP were compared between genders, and after the population was split into pre (≤50 years)- and post (>50 years)-menopausal ages. In WB, platelet-total WBC densities were comparable in men and women. The phagocytic cell composition differed (p ≤ 0.04). After dividing by ages, phagocytic cell discrepancies were linked to women > 50 years (p ≤ 0.05), and differences emerged in lymphocyte counts (lower in >50 years groups, within and between genders, p ≤ 0.05). In PRP, densities were significantly higher, but the PRP/WB ratios varied according to blood cell (lower for phagocytic cells) and between subjects (more favorable at a lower density of a particular blood cell in WB). This "system compensatory efficiency" reduced/reverted PRP differences in the leukocyte composition between genders/age-sex groups in WB. In PRP, neutrophils were higher in younger men than older women (p < 0.05). WB lymphocyte differences between age-sex groups persisted. Age is a more determining factor than sex in the preparation of PRP. Post-menopause, sexual dimorphism strongly influences the composition of leukocytes, also conditioned by the capture efficiency of the system. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation.uri | https://doi.org/10.3390/jcm11061683 | es_ES |
dc.rights | Atribución 4.0 Internacional (CC BY 4.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Aging | es_ES |
dc.subject | Blood separation–concentration system | es_ES |
dc.subject | Leukocytes | es_ES |
dc.subject | Sexual dimorphism | es_ES |
dc.subject | Platelet-rich plasma | es_ES |
dc.subject | Envejecimiento | es_ES |
dc.subject | Leucocitos | es_ES |
dc.subject | Dimorfismo sexual | es_ES |
dc.subject | Plasma rico en plaquetas | es_ES |
dc.title | Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Journal of Clinical Medicine | es_ES |
UDC.volume | 11 | es_ES |
UDC.issue | 6 | es_ES |
UDC.startPage | 1683 | es_ES |
dc.identifier.doi | 10.3390/jcm11061683 |
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