Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma

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Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich PlasmaAuthor(s)
Date
2022-03Citation
Trevissón, B.; Becerro-de-Bengoa-Vallejo, R.; Sevillano, D.; González, N.; Losa-Iglesias, M.E.; López-López, D.; Alou, L. Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma. J. Clin. Med. 2022, 11, 1683. https://doi.org/10.3390/jcm11061683
Abstract
[Abstract] Few studies have checked the impact of the hormonal/immunological dimorphism of patients on the cellular composition of platelet-rich plasma products (PRP). Whole blood (WB) from 26 volunteers was concentrated using a device previously characterized. Platelet and white blood cell (WBC) counts in WB and PRP were compared between genders, and after the population was split into pre (≤50 years)- and post (>50 years)-menopausal ages. In WB, platelet-total WBC densities were comparable in men and women. The phagocytic cell composition differed (p ≤ 0.04). After dividing by ages, phagocytic cell discrepancies were linked to women > 50 years (p ≤ 0.05), and differences emerged in lymphocyte counts (lower in >50 years groups, within and between genders, p ≤ 0.05). In PRP, densities were significantly higher, but the PRP/WB ratios varied according to blood cell (lower for phagocytic cells) and between subjects (more favorable at a lower density of a particular blood cell in WB). This "system compensatory efficiency" reduced/reverted PRP differences in the leukocyte composition between genders/age-sex groups in WB. In PRP, neutrophils were higher in younger men than older women (p < 0.05). WB lymphocyte differences between age-sex groups persisted. Age is a more determining factor than sex in the preparation of PRP. Post-menopause, sexual dimorphism strongly influences the composition of leukocytes, also conditioned by the capture efficiency of the system.
Keywords
Aging
Blood separation–concentration system
Leukocytes
Sexual dimorphism
Platelet-rich plasma
Envejecimiento
Leucocitos
Dimorfismo sexual
Plasma rico en plaquetas
Blood separation–concentration system
Leukocytes
Sexual dimorphism
Platelet-rich plasma
Envejecimiento
Leucocitos
Dimorfismo sexual
Plasma rico en plaquetas
Editor version
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Atribución 4.0 Internacional (CC BY 4.0)