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dc.contributor.authorVarela-Aramburu, Silvia
dc.contributor.authorSu, Lu
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorMorgese, Giulia
dc.contributor.authorSchoenmakers, Sandra M. C.
dc.contributor.authorCardinaels, Ruth
dc.contributor.authorPalmans, Anja
dc.contributor.authorMeijer, E. W.
dc.date.accessioned2022-03-11T13:23:33Z
dc.date.available2022-03-11T13:23:33Z
dc.date.issued2021-10-18
dc.identifier.citationVarela-Aramburu, S.; Su, L.; Mosquera, J.; Morgese, G.; Schoenmakers, S. M. C.; Cardinaels, R.; Palmans, A. R. A.; Meijer, E. W. Introducing Hyaluronic Acid into Supramolecular Polymers and Hydrogels. Biomacromolecules 2021, 22, 4633-4641. DOI: 10.1021/acs.biomac.1c00927es_ES
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.urihttp://hdl.handle.net/2183/29968
dc.description.abstract[Abstract] The use of supramolecular polymers to construct functional biomaterials is gaining more attention due to the tunable dynamic behavior and fibrous structures of supramolecular polymers, which resemble those found in natural systems, such as the extracellular matrix. Nevertheless, to obtain a biomaterial capable of mimicking native systems, complex biomolecules should be incorporated, as they allow one to achieve essential biological processes. In this study, supramolecular polymers based on water-soluble benzene-1,3,5-tricarboxamides (BTAs) were assembled in the presence of hyaluronic acid (HA) both in solution and hydrogel states. The coassembly of BTAs bearing tetra(ethylene glycol) at the periphery (BTA-OEG4) and HA at different ratios showed strong interactions between the two components that led to the formation of short fibers and heterogeneous hydrogels. BTAs were further covalently linked to HA (HA-BTA), resulting in a polymer that was unable to assemble into fibers or form hydrogels due to the high hydrophilicity of HA. However, coassembly of HA-BTA with BTA-OEG4 resulted in the formation of long fibers, similar to those formed by BTA-OEG4 alone, and hydrogels were produced with tunable stiffness ranging from 250 to 700 Pa, which is 10-fold higher than that of hydrogels assembled with only BTA-OEG4. Further coassembly of BTA-OEG4 fibers with other polysaccharides showed that except for dextran, all polysaccharides studied interacted with BTA-OEG4 fibers. The possibility of incorporating polysaccharides into BTA-based materials paves the way for the creation of dynamic complex biomaterials.es_ES
dc.description.sponsorshipThe authors acknowledge the ICMS Animation Studio for providing the artwork. S.V.-A. and G.M. acknowledge the funding received by Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands Organization for Scientific Research (024.003.013). J.M. acknowledges a Marie Skłodowska-Curie postdoctoral fellowship (794016) for financial support. G.M. acknowledges the funding received by the Swiss National Science Foundation (SNSF “Early PostDoc Mobility” P2EZP2-178435). R.C. acknowledges TA Instruments for providing the DHR-3 rheometer under the Young Distinguished Rheologist Award instrument grant. S.S. and E.W.M acknowledge the European Research Council (H2020-EU.1.1., SYNMAT project, ID 788618).es_ES
dc.description.sponsorshipNetherlands Organisation for Scientific Research; 024.003.013es_ES
dc.description.sponsorshipSwiss National Science Foundation; P2EZP2-178435es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/788618es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/794016es_ES
dc.relation.urihttps://doi.org/10.1021/acs.biomac.1c00927es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacionales_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIntroducing Hyaluronic Acid into Supramolecular Polymers and Hydrogelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleBiomacromoleculeses_ES
UDC.volume22es_ES
UDC.issue11es_ES
UDC.startPage4633es_ES
UDC.endPage4641es_ES
dc.identifier.doi10.1021/acs.biomac.1c00927


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