Effectiveness of Surgical Hand Antisepsis Using Chlorhexidine Digluconate and Parachlorometaxylenol Hand Scrub
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http://hdl.handle.net/2183/29928
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Effectiveness of Surgical Hand Antisepsis Using Chlorhexidine Digluconate and Parachlorometaxylenol Hand ScrubAutor(es)
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2018-10Cita bibliográfica
Vallejo, Ricardo Becerro de Bengoa PhD, DPM, DHLa; Fernandez, David Sevillano PhDa; Cervera, Luis Alou PhDb; Aragón, Laura Martín PhDa; Iglesias, Marta Elena Losa PhDc,∗; Yurrita, Luis Rodolfo Collado MD, PhDa; Lopez, Daniel Lopezd Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub, Medicine: October 2018 - Volume 97 - Issue 42 - p e12831 doi: 10.1097/MD.0000000000012831
Resumo
[Abstract] Background:
Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy “in vivo.
Methods:
We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1). We assessed bacterial load after a prewash with soft soap, immediately after application of an antiseptic, and 3 hours after application and wearing of sterile, powder-free gloves. Our procedures followed those specified by European Norm (EN) 12791 for evaluating surgical hand antiseptics and using cotton swab for fingertips and fingernails.
Results:
Chlorhexidine digluconate 4% and PCMX 3% did not decrease bacterial load on the hands. The bactericidal performances of chlorhexidine digluconate 4% and PCMX 3% did not differ significantly. Chlorhexidine digluconate 4% and PCMX 3% increased bacterial load on the fingertips after participants had worn gloves for 3 hours. Fingernails had greater bacterial loads than skin on the fingertips.
Conclusions:
Chlorhexidine digluconate 4% and PCMX 3% had similar bactericidal efficacy, but they failed to meet the EN 12791 efficacy standard. Fingernails should be a particular focus of antisepsis in preparation for surgery.
The trial was registered at ClinicalTrials.gov (ID: NCT02500758).
Palabras chave
Antisepsis
Antisepsia
Randomized controlled trial
Ensayo controlado aleatorizado
Surgical site infection
Infección del área quirúrgica
Antisepsia
Randomized controlled trial
Ensayo controlado aleatorizado
Surgical site infection
Infección del área quirúrgica
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Atribución-NoComercial 4.0 Internacional