Genetic biomarkers in osteoarthritis: a quick overview
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Genetic biomarkers in osteoarthritis: a quick overviewAutor(es)
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2021-11-10Cita bibliográfica
Rego-Pérez I, Durán-Sotuela A, Ramos-Louro P, Blanco FJ. Genetic biomarkers in osteoarthritis: a quick overview. Fac Rev. 2021;10:78
Resumo
[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. Therefore, the efforts on OA research are focused mainly on the discovery of therapeutic targets and reliable biomarkers that permit the early identification of different OA-related parameters such as diagnosis, prognosis, or phenotype identification. To date, potential candidate protein biomarkers have been associated with different aspects of the disease; however, there is currently no gold standard. In this sense, genomic data could act as complementary biomarkers of diagnosis and prognosis or even help to identify therapeutic targets of the disease. In this review, we will describe the most recent advances in genetic biomarkers in OA over the past three years.
Palabras chave
Osteoarthritis
Biomakers
Genetics
Biomakers
Genetics
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Dereitos
Atribución 3.0 España
ISSN
2732-432X