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Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years
dc.contributor.author | Caravan, Peter | |
dc.contributor.author | Esteban-Gómez, David | |
dc.contributor.author | Rodríguez-Rodríguez, Aurora | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.date.accessioned | 2021-12-03T09:49:35Z | |
dc.date.available | 2021-12-03T09:49:35Z | |
dc.date.issued | 2019-06-19 | |
dc.identifier.citation | P. Caravan, D. Esteban-Gómez, A. Rodríguez-Rodríguez and C. Platas-Iglesias, Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years, Dalt. Trans., 2019, 48, 11161–1118. DOI: 10.1039/C9DT01948K. | es_ES |
dc.identifier.issn | 1477-9234 | |
dc.identifier.uri | http://hdl.handle.net/2183/29065 | |
dc.description.abstract | [Abstract] The water exchange rates of water molecules coordinated to the metal ion in lanthanide complexes have been profusely investigated during the last 25 years, especially in the case of Gd3+ and Eu3+ complexes. This is mainly related to the important application of some Gd3+ complexes as contrast agents in magnetic resonance imaging (MRI), and the intensive investigation of Eu3+ complexes as contrast agent candidates providing contrast through the chemical exchange saturation transfer mechanism (CEST). Both applications require a fine tunning of the exchange rate of the coordinated water molecule to yield optimal response. Herein we review the progress made in this field to control water exchange in a rational way through ligand design, providing relationships between the observed trends, the structures of the complexes and the mechanisms responsible for the water exchange reaction. | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad; CTQ2016-76756-P | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431B 2017/59 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431D 2017/01 | es_ES |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades; PRX18/00201 | es_ES |
dc.description.sponsorship | Estados Unidos. U.S. National Institute of Biomedical Imaging and Bioengineering; R01EB009062 | es_ES |
dc.description.sponsorship | Estados Unidos; National Institute of Diabetes and Digestive and Kidney Diseases; U01DK104302 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation.uri | https://doi.org/10.1039/C9DT01948K | es_ES |
dc.title | Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Dalton Transactions | es_ES |
UDC.volume | 48 | es_ES |
UDC.issue | 30 | es_ES |
UDC.startPage | 11161 | es_ES |
UDC.endPage | 11180 | es_ES |
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