Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years
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Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 yearsData
2019-06-19Cita bibliográfica
P. Caravan, D. Esteban-Gómez, A. Rodríguez-Rodríguez and C. Platas-Iglesias, Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years, Dalt. Trans., 2019, 48, 11161–1118. DOI: 10.1039/C9DT01948K.
Resumo
[Abstract] The water exchange rates of water molecules coordinated to the metal ion in lanthanide complexes have been profusely investigated during the last 25 years, especially in the case of Gd3+ and Eu3+ complexes. This is mainly related to the important application of some Gd3+ complexes as contrast agents in magnetic resonance imaging (MRI), and the intensive investigation of Eu3+ complexes as contrast agent candidates providing contrast through the chemical exchange saturation transfer mechanism (CEST). Both applications require a fine tunning of the exchange rate of the coordinated water molecule to yield optimal response. Herein we review the progress made in this field to control water exchange in a rational way through ligand design, providing relationships between the observed trends, the structures of the complexes and the mechanisms responsible for the water exchange reaction.
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1477-9234