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Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids
dc.contributor.author | Dalmao-Fernández, Andrea | |
dc.contributor.author | Hermida Gómez, Tamara | |
dc.contributor.author | Lund, Jenny | |
dc.contributor.author | Vázquez-Mosquera, María E. | |
dc.contributor.author | Rego-Pérez, Ignacio | |
dc.contributor.author | Garesse, Rafael | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Fernández-Moreno, Mercedes | |
dc.date.accessioned | 2021-09-22T08:53:18Z | |
dc.date.issued | 2022-05 | |
dc.identifier.citation | Dalmao-Fernández A, Hermida-Gómez T, Lund J, Vazquez-Mosquera ME, Rego-Pérez I, Garesse R, Blanco FJ, Fernández-Moreno M. Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids. Cytotherapy. 2021 May;23(5):399-410. | es_ES |
dc.identifier.issn | 1465-3249 | |
dc.identifier.uri | http://hdl.handle.net/2183/28504 | |
dc.description.abstract | [Abstract] With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness with a low grade of chronic inflammation. Mitochondrial dysfunction is well documented in OA and has the capacity to alter chondrocyte and synoviocyte function. Transmitochondrial cybrids are suggested as a useful cellular model to study mitochondrial biology in vitro, as they carry different mitochondrial variants with the same nuclear background. The aim of this work was to study mitochondrial and metabolic function of cybrids with mitochondrial DNA from healthy (N) and OA donors. In this work, the authors demonstrate that cybrids from OA patients behave differently from cybrids from N donors in several mitochondrial parameters. Furthermore, OA cybrids behave similarly to OA chondrocytes. These results enhance our understanding of the role of mitochondria in the degeneration process of OA and present cybrids as a useful model to study OA pathogenesis. | es_ES |
dc.description.sponsorship | This study was supported by grants from Fondo de Investigación Sanitaria, Centro de investigación biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina CB06/01/0040, Spain; RETIC-RIER-RD16/0012/0002; PI12/00329; PI14/01254; PI16/02124; PIE16/00054; PRB3-ISCIII-PT17/0019; and PI17/00210, integrated into the National Plan for Scientific Program, Development and Technological Innovation 2013–2016, and funded by the El Instituto de Salud Carlos III, General Subdirection of Assessment and Promotion of Research–European Regional Development Fund “A way of making Europe.” MF-M is supported by Contrato Centro de investigación biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina. AD-F is supported by FIS PI17/00210 and was the beneficiary of short-term scientific missions from MitoEAGLE (COST Action CA15203) for a research stat at the University of Oslo. JL is supported by the Universty of Oslo. MEV-M is supported by FIS PI16/02124. IR-P is supported by Contrato Miguel Servet tipo II-Fondo de Investigación Sanitaria (CPII17/00026). | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16%2F0012%2F0002/ES/Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER) | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Acción Estratégica de Salud/PI12%2F00329/ES/PROYECTO PROTEOMA HUMANO ESPAÑOL: Aplicacion en Enfermedades Reumatologicas | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI14%2F01254/ES/Diseño de un modelo celular de cíbridos transmitocondriales para la búsqueda de biomarcadores epigenéticos para el diagnóstico de distintos fenotipos de artrosis | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F02124/ES/Determinación de índices predictivos de diagnóstico y pronóstico de artrosis de rodilla mediante la validación de biomarcadores proteicos | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PIE16%2F00054/ES/Identification of clinical phenotypes on Osteoarthritis (OA) disease through Big Data approach | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PRB3-ISCIII-PT17%2F0019 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F00210/ES/IDENTIFICACION DE MARCADORES GENETICOS MITOCONDRIALES DE PROGRESION RAPIDA DE ARTROSIS DE RODILLA MEDIANTE TECNICAS DE SECUENCIACION MASIVA. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F00210/ES/IDENTIFICACION DE MARCADORES GENETICOS MITOCONDRIALES DE PROGRESION RAPIDA DE ARTROSIS DE RODILLA MEDIANTE TECNICAS DE SECUENCIACION MASIVA. | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; CPII17/00026 | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.uri | https://doi.org/10.1016/j.jcyt.2020.08.010 | es_ES |
dc.title | Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/embargoedAccess | es_ES |
dc.date.embargoEndDate | 2022-05-01 | es_ES |
dc.date.embargoLift | 2022-05-01 | |
UDC.journalTitle | Cytotherapy | es_ES |
UDC.volume | 23 | es_ES |
UDC.issue | 5 | es_ES |
UDC.startPage | 399 | es_ES |
UDC.endPage | 410 | es_ES |
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