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Relationship between the dynamics of telomere loss in peripheral blood leukocytes from osteoarthritis patients and mitochondrial DNA haplogroup
dc.contributor.author | Guillén, Rebeca | |
dc.contributor.author | Otero, Fátima | |
dc.contributor.author | Mosquera, Alejandro | |
dc.contributor.author | Rego-Pérez, Ignacio | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Fernández García, José Luis | |
dc.date.accessioned | 2021-09-21T11:53:41Z | |
dc.date.issued | 2021-03-01 | |
dc.identifier.citation | Fajardo RG, Fariña FO, Rey AM, Rego-Pérez I, Blanco FJ, García JLF. Relationship between the dynamics of telomere loss in peripheral blood leukocytes from osteoarthritis patients and mitochondrial DNA haplogroup. J Rheumatol. 2021 Oct;48(10):1603-1607. | es_ES |
dc.identifier.issn | 0315-162X | |
dc.identifier.uri | http://hdl.handle.net/2183/28488 | |
dc.description.abstract | [Abstract] Objective: To evaluate the evolution of telomere length from peripheral blood leukocytes (PBLs) in subjects from the Osteoarthritis Initiative (OAI) cohort in relation to the incidence of osteoarthritis (OA), and to explore its possible interactive influence with the mitochondrial DNA (mtDNA) haplogroup. Methods: Dynamics of telomere sequence loss were quantified in PBLs from initially healthy individuals (without symptoms or radiological signs), 78 carrying the mtDNA cluster HV, and 47 with cluster JT, from the OAI, during a 72-month follow-up period. The incidence of knee OA during this period (n = 39) was radiographically established when Kellgren-Lawrence (KL) score increased from < 2 at recruitment, to ≥ 2 at the end of 72 months of follow-up. Multivariate analysis using binary logistic regression was performed to assess PBL telomere loss and mtDNA haplogroups as associated risk factors of incidence of knee OA. Results: Carriers of cluster HV showed knee OA incidence twice that of the JT carriers (n = 30 vs 9). The rate of PBL telomere loss was higher in cluster HV carriers and in individuals with incident knee OA. Multivariate analysis showed that the dynamics of PBL telomere shortening can be a consistent risk marker of knee OA incidence. Subjects with nonincident knee OA showed a slower telomere loss than those with incident knee OA; the difference was more significant in carriers of cluster JT than in HV. Conclusion: An increased rate of telomere loss in PBLs may reflect a systemic accelerated senescence phenotype that could be potentiated by the mitochondrial function, increasing the susceptibility of developing knee OA. | es_ES |
dc.description.sponsorship | The work was supported by grants PI17/01987 and PI16/02124 from Fondo de Investigaciones Sanitarias (FIS), Instituto de Salud Carlos III, Spain, a part of the National Plan for Scientific Program, Development and Technological Innovation, 2013-2016, and the ISCIII-General Subdirection of Assessment and Promotion of Research-European Regional Development Fund (FEDER) ‘A way of making Europe’, and grant IN607A 2017/11 from Xunta de Galicia. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F01987/ES/ANALISIS DINAMICO DE PARAMETROS DE FISIOLOGIA TELOMERICA, COMO MARCADORES DE INCIDENCIA Y/O PROGRESION DE OSTEOARTITIS | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A 2017/11 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F02124/ES/Determinación de índices predictivos de diagnóstico y pronóstico de artrosis de rodilla mediante la validación de biomarcadores proteicos | |
dc.language.iso | eng | es_ES |
dc.publisher | The Journal of Rheumatology Publishing | es_ES |
dc.relation.uri | https://doi.org/10.3899/jrheum.201316 | es_ES |
dc.rights | This is a pre-copyediting, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version is available online at The Journal of Rheumatology web page | es_ES |
dc.title | Relationship between the dynamics of telomere loss in peripheral blood leukocytes from osteoarthritis patients and mitochondrial DNA haplogroup | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
dc.date.embargoEndDate | 2022-03-01 | es_ES |
dc.date.embargoLift | 2022-03-01 | |
UDC.journalTitle | Journal of Rheumatology | es_ES |
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