Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview
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Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overviewFecha
2020-08-10Cita bibliográfica
Carballo-Pedrares N, Fuentes-Boquete I, Díaz-Prado S, Rey-Rico A. Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview. Pharmaceutics. 2020;12:752.
Resumen
[Abstract]
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various
regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular,
or neural tissues disorders as well as wound healing. By a minimally invasive administration,
these systems can provide a spatially and temporarily defined supply of specific gene sequences
into the target tissue cells that are overexpressing or silencing the original gene, which can promote
natural repairing mechanisms to achieve the desired effect. In the present work, we provide an
overview of the most avant-garde approaches using various hydrogels systems for controlled delivery
of therapeutic nucleic acid molecules in different regenerative medicine approaches.
Palabras clave
Musculoskeletal tissue
Cardiovascular tissue
Wound healing
Nervous tissue
Gene therapy
Controlled delivery
Hydrogels
Nonviral vectors
Cardiovascular tissue
Wound healing
Nervous tissue
Gene therapy
Controlled delivery
Hydrogels
Nonviral vectors
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Derechos
Creative Commons Attribution 4.0 International Licence (CC-BY 4.0)
ISSN
1999-4923