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The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use
dc.contributor.author | Salamini-Montemurri, Martín | |
dc.contributor.author | Lamas, Mónica | |
dc.contributor.author | Barreiro-Alonso, Aida | |
dc.contributor.author | Vizoso-Vázquez, Ángel | |
dc.contributor.author | Rodríguez-Belmonte, Esther | |
dc.contributor.author | Quindós-Varela, María | |
dc.contributor.author | Cerdán, María Esperanza | |
dc.date.accessioned | 2020-05-20T11:31:00Z | |
dc.date.available | 2020-05-20T11:31:00Z | |
dc.date.issued | 2020-04-21 | |
dc.identifier.citation | Salamini-Montemurri, M., Lamas-Maceiras, M., Barreiro-Alonso, A., Vizoso-Vázquez, Á., Rodríguez-Belmonte, E., Quindós-Varela, M., & Cerdán, M. E. (2020). The Challenges and Opportunities of LncRNAs in Ovarian Cancer Research and Clinical Use. Cancers, 12(4), 1020. doi:10.3390/cancers12041020 | es_ES |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | http://hdl.handle.net/2183/25604 | |
dc.description.abstract | [Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor. In this review we aim to highlight the importance of long non-coding RNAs (lncRNAs) in diagnosis, prognosis and treatment choice, to make progress towards increasingly personalized medicine in this malignancy. We review the effects of lncRNAs associated with ovarian cancer in the context of cancer hallmarks. We also discuss the molecular mechanisms by which lncRNAs become involved in cellular physiology; the onset, development and progression of ovarian cancer; and lncRNAs’ regulatory mechanisms at the transcriptional, post-transcriptional and post-translational stages of gene expression. Finally, we compile a series of online resources useful for the study of lncRNAs, especially in the context of ovarian cancer. Future work required in the field is also discussed along with some concluding remarks. | es_ES |
dc.description.sponsorship | This work was funded by Plan Estatal I + D + I by the Instituto de Salud Carlos III (ISCIII, Spain) under grant agreement AES number PI18/01714, cofounded by Fondo Europeo de Desarrollo Regional-FEDER (The European Regional Development Fund-ERDF) “A way of Making Europe,” and by Xunta de Galicia (Consolidación Grupos Referencia Competitiva contract number ED431C 2016-012). M.S.M. was funded by a predoctoral fellowship from FPU-2018 (Spain) | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2016-012 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI18%2F01714/ES/BUSQUEDA DE INTERACCIONES HMGB-LNCRNAS UTILES EN DIAGNOSTICO CANCER DE OVARIO/ | |
dc.relation.uri | https://doi.org/10.3390/cancers12041020 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Diagnosis | es_ES |
dc.subject | Prognosis | es_ES |
dc.subject | Therapy | es_ES |
dc.subject | Molecular mechanisms | es_ES |
dc.subject | Bioinformatics tools | es_ES |
dc.title | The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Cancers | es_ES |
UDC.volume | 12 | es_ES |
UDC.issue | 4 | es_ES |
UDC.startPage | 1020 | es_ES |
dc.identifier.doi | 10.3390/cancers12041020 |
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