Buscar
Mostrando ítems 1-10 de 14
Detection of protein interactions based on GFP fragment complementation by fluorescence microscopy and spectrofluorometry
(Future Science, 2008)
[Abstract] We have developed a set of simple modifications of the green fluorescent protein (GFP)fragment reassembly assay in bacteria that permits: (i)fluorescent microscopy visualization of GFP reassembly only 1-2 h after ...
Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart
(PLoS, 2011)
[Abstract] Background. Myocardin (MYOCD), a potent transcriptional coactivator of smooth muscle (SM) and cardiac genes, is upregulated in failing myocardium in animal models and human end-stage heart failure (HF). However, ...
Russian comparative embryology takes form: a conceptual metamorphosis toward “evo-devo”
(Wiley, 2012)
[Abstract] This essay recapitulates major paths followed by the Russian tradition of what we refer to today as evolutionary developmental biology (“evo-devo”). The article addresses several questions regarding the conceptual ...
Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease
(Springer, 2016)
[Abstract] There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal ...
A Novel Heterozygous Intronic Mutation in the FBN1 Gene Contributes to FBN1 RNA Missplicing Events in the Marfan Syndrome
(Hindawi, 2018)
[Abstract] Marfan syndrome (MFS) is an autosomal dominantly inherited connective tissue disorder, mostly caused by mutations in the fibrillin-1 (FBN1) gene. We, by using targeted next-generation sequence analysis, identified ...
A MicroRNA transcription factor blueprint for early atrial arrhytmogenic remodeling
(Hindawi, 2015)
[Abstract] Spontaneous self-terminating atrial fibrillation (AF) is one of the most common heart rhythm disorders, yet the regulatory molecular mechanisms underlying this syndrome are rather unclear. MicroRNA (miRNA) ...
Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation
(Springer, 2018)
[Abstract] There is growing evidence that putative gene regulatory networks including cardio-enriched transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target genes along with downstream ...
In search of novel targets for heart disease: myocardin and myocardin-related transcriptional cofactors
(Hindawi, 2012)
[Abstract] Growing evidence suggests that gene-regulatory networks, which are responsible for directing cardiovascular development, are altered under stress conditions in the adult heart. The cardiac gene regulatory network ...
Exploring the past through the present
(Wiley, 2013)
Intron retention generates ANKRD1 splice variants that are co-regulated with the main transcript in normal and failing myocardium
(Elsevier, 2009-03-31)
[Abstract] The cardiac ankyrin repeat domain 1 protein (ANKRD1, also known as CARP) has been extensively characterized with regard to its proposed functions as a cardio-enriched transcriptional co-factor and stress-inducible ...