Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation
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Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillationData
2018Cita bibliográfica
Mikhailov AT, Torrado M. Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation. J Mol Med. 2018;96(7):601-610
Resumo
[Abstract] There is growing evidence that putative gene regulatory networks including cardio-enriched transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target genes along with downstream non-coding RNAs can play a potentially important role in the process of adaptive and maladaptive atrial rhythm remodeling. In turn, expression of atrial fibrillation-associated transcription factors is under the control of upstream regulatory non-coding RNAs. This review broadly explores gene regulatory mechanisms associated with susceptibility to atrial fibrillation—with key examples from both animal models and patients—within the context of both cardiac transcription factors and non-coding RNAs. These two systems appear to have multiple levels of cross-regulation and act coordinately to achieve effective control of atrial rhythm effector gene expression. Perturbations of a dynamic expression balance between transcription factors and corresponding non-coding RNAs can provoke the development or promote the progression of atrial fibrillation. We also outline deficiencies in current models and discuss ongoing studies to clarify remaining mechanistic questions. An understanding of the function of transcription factors and non-coding RNAs in gene regulatory networks associated with atrial fibrillation risk will enable the development of innovative therapeutic strategies.
Palabras chave
Atrial fibrillation
Gene regulatory networks
Transcription factors
Non-coding RNAs
Atrial myocardium
Gene regulatory networks
Transcription factors
Non-coding RNAs
Atrial myocardium
Descrición
Review
Versión do editor
Dereitos
The final publication is avaliable at Springer Link
ISSN
0946-2716
1432-1440
1432-1440