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Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis
(MDPI, 2022-06-12)
[Abstract] Control of excessive mitochondrial oxidative stress could provide new targets for both preventive and therapeutic interventions in the treatment of chronic inflammation or any pathology that develops under an ...
Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids
(Elsevier, 2022-05)
[Abstract] With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness with a low grade of chronic inflammation. Mitochondrial dysfunction ...
Histone Extraction From Human Articular Cartilage for the Study of Epigenetic Regulation in Osteoarthritis
(MDPI, 2022-03-20)
[Abstract] Osteoarthritis (OA) is a chronic disease that affects articular cartilage, causing its degeneration. Although OA is one of the most prevalent pathologies globally, there are no definitive treatments available. ...
Exploring high-throughput immunoassays for biomarker validation in rheumatic diseases in the context of the human proteome project
(ACS Publications, 2022-12-07)
[Abstract] Rheumatic diseases are high prevalence pathologies with different etiology and evolution and low sensitivity in clinical diagnosis. Therefore, it is necessary to develop an early diagnosis method which allows ...
Antifibrotic Effect of Brown Algae-Derived Fucoidans on Osteoarthritic Fibroblast-Like Synoviocytes
(Elsevier, 2022-01-12)
[Abstract] Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as ...