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dc.contributor.authorPech-Puch, Dawrin
dc.contributor.authorRodríguez, Jaime
dc.contributor.authorCautain, Bastien
dc.contributor.authorSandoval-Castro, Carlos Alfredo
dc.contributor.authorJiménez, Carlos
dc.date.accessioned2019-08-12T10:55:42Z
dc.date.available2019-08-12T10:55:42Z
dc.date.issued2019-07-16
dc.identifier.citationPech-Puch, D.; Rodríguez, J.; Cautain, B.; Sandoval-Castro, C.A.; Jiménez, C. Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean. Mar. Drugs 2019, 17, 416.es_ES
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/2183/23716
dc.description.abstract[Abstract] Two new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3,13(16),14-trien-2-one (3), 3β,19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (4) and spongian diterpene 17 (5), the furanoditerpene ambliol C (6), and the sesterterpene scalarin (7), were isolated from the methanolic extract of the sponge Spongia tubulifera, collected in the Mexican Caribbean. The planar structures of the new compounds were elucidated by 1D/2D NMR and IR spectroscopic analysis, high resolution electrospray mass spectrometry (HRESIMS), and comparison of their spectral data with those reported in the literature. Absolute configurations were determined by comparison of the experimental electronic circular dichroism (ECD) spectrum with those calculated by time-dependent density functional theory (TDDFT). Compounds 1, 4, and 6 displayed weak cytotoxic activity against different human tumour cell lines.es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad; AGL2015-63740-C2-2-Res_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad; RTC-2016-4611-1es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/md17070416es_ES
dc.rightsAtribución 4.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/es/*
dc.subjectSpongian furanoditerpeneses_ES
dc.subjectMarine spongees_ES
dc.subjectSpongia tubuliferaes_ES
dc.subjectECD-TDDFTes_ES
dc.subjectCytotoxicityes_ES
dc.titleCytotoxic furanoditerpenes from the sponge Spongia tubulifera collected in the Mexican Caribbeanes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleMarine Drugses_ES
UDC.volume17es_ES
UDC.issue7es_ES
UDC.startPage416es_ES


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