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dc.contributor.authorMartínez-Ramonde, T.
dc.contributor.authorAlonso, N.
dc.contributor.authorCordido, Fernando
dc.contributor.authorCervelló, E.
dc.contributor.authorCañizares, Angelina
dc.contributor.authorMartínez-Peinado, P.
dc.contributor.authorSempere, J.M.
dc.contributor.authorRoche, E.
dc.date.accessioned2019-02-20T11:45:13Z
dc.date.available2019-02-20T11:45:13Z
dc.date.issued2014-05-05
dc.identifier.citationMartínez-Ramonde T, Alonso N, Cordido F, Cervelló E, Cañizares A, Martínez-Peinado P, Sempere JM, Roche E. Importance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjects. Exp Clin Endocrinol Diabetes. 2014 Jun;122(6):334-40.es_ES
dc.identifier.issn0947-7349
dc.identifier.urihttp://hdl.handle.net/2183/21884
dc.description.abstract[Abstract] The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic control (honeymoon phase). Therefore, the extension of this situation could have evident benefits in subsequent diabetes management. We aimed to study the influence of regular physical activity before and after the onset of the disease. We did an observational study of 2 groups of type 1 diabetic patients from onset to a 2-year period. One group (n=8) exercised regularly (5 or more hours/week) before onset and continued doing so with the same regularity. The second group (n=11) either did not perform physical activity or did so sporadically. Circulating glycated haemoglobin (HbA1c), C-peptide, protein carbonyls and basal cytokine levels were determined at the beginning and at the end of the 1st and 2nd year. The more active group debuted with and maintained significantly lower HbA1c levels and insulin requirements compared to the more sedentary group. C-peptide levels were only significantly higher in the active group at the moment of onset compared to the sedentary group. In addition, determination of basal circulating cytokines revealed a large variability between individuals but no significant differences when comparing the groups. Altogether, the obtained results seem to indicate that physical activity allows a better control at the moment of onset regarding glycaemic control, residual endocrine pancreatic mass and subsequent insulin requirements.es_ES
dc.language.isoenges_ES
dc.publisherThiemees_ES
dc.relation.urihttp://dx.doi.org/10.1055/s-0034-1372581es_ES
dc.subjectC-peptidees_ES
dc.subjectBeta-cell masses_ES
dc.subjectGlycated heamoglobines_ES
dc.subjectInflammationes_ES
dc.titleImportance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjectses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleExperimental and Clinical Endocrinology & Diabeteses_ES
UDC.volume122es_ES
UDC.issue6es_ES
UDC.startPage334es_ES
UDC.endPage340es_ES


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