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dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorLópez-López, Rocío
dc.contributor.authorMaseda, Ana
dc.contributor.authorBuján, Ana
dc.contributor.authorRodríguez-Villamil, José Luis
dc.contributor.authorMillán-Calenti, José Carlos
dc.date.accessioned2018-12-11T12:42:26Z
dc.date.issued2018-11-15
dc.identifier.citationLorenzo-López L, López-López R, Maseda A, Buján A, Rodríguez-Villamil JL, Millán-Calenti JC. Changes in frailty status in a community-dwelling cohort of older adults: the VERISAÚDE study. Maturitas. 2019; 11:54-60es_ES
dc.identifier.issn0378-5122
dc.identifier.urihttp://hdl.handle.net/2183/21496
dc.description.abstract[Abstract] Objectives: Greater understanding of changes in the degree of frailty is important for clarifying the natural history of frailty and may help clinical decision-making regarding preventive interventions. The objectives of this study were to explore natural frailty transition rates at 1-year follow-up and to identify the main determinants of such transitions. Study design: Prospective longitudinal study covering a representative sample of community-dwelling older adults aged ≥65 years (n = 749) at baseline, and transition information at 1-year follow-up (n = 537). Mean outcome measures: The assessment of frailty status was based on phenotypic criteria (unintentional weight loss, weakness, exhaustion, slow walking speed, low physical activity). Frailty transitions (progressed, regressed, no change, or death) and associated factors were assessed. Results: Most participants remained unchanged from their baseline status (57.1% non-frail, 83.4% pre-frail, 66.7% frail). Regarding frailty transitions, 42.9% of non-frail older adults at baseline had progressed to a pre-frail status by the 1-year follow-up, and 7.9% of pre-frail older adults had become frail. Importantly, 33.3% of frail older adults regressed to a pre-frail status and 8.7% of pre-frail adults had regressed to a non-frail status. Non-frail females tended to progress to pre-frailty significantly more than males (p = 0.006), and mortality was higher among participants classified as frail at baseline (10.7%). Logistic regression showed that the main determinants of worsening frailty were hearing impairment (OR 3.180; 95% CI 1.078–9.384), congestive heart failure (OR 10.864; 95% CI 1.379–85.614), and polypharmacy (OR 2.572, 95% CI 1.096–6.037). Conclusion: Our results confirm the dynamic of frailty and the bidirectional nature of frailty transitions, and indicate the need for preventing and treating these conditions in later life in order to minimize the burden of frailty.es_ES
dc.description.sponsorshipXunta de Galicia; EM 2012/100es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2017/49es_ES
dc.description.sponsorshipXunta de Galicia; IN607C, 2016/08es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.urihttps://doi.org/10.1016/j.maturitas.2018.11.006es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectFrailty transitionses_ES
dc.subjectPre-frailtyes_ES
dc.subjectOlder adultses_ES
dc.subjectMortalityes_ES
dc.subjectHearing impairmentes_ES
dc.titleChanges in frailty status in a community-dwelling cohort of older adults: the VERISAÚDE studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/embargoedAccesses_ES
dc.date.embargoEndDate2019-11-15es_ES
dc.date.embargoLift2019-11-15
UDC.journalTitleMaturitases_ES
UDC.volume119es_ES
UDC.startPage54es_ES
UDC.endPage60es_ES


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