Generation of osteoarthritis and healthy mesenchymal cell lines for research on regenerative medicine for osteoarthritis
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TitleGeneration of osteoarthritis and healthy mesenchymal cell lines for research on regenerative medicine for osteoarthritis
Piñeiro-Ramil M, Castro-Viñuelas R, Sanjurjo-Rodríguez C, Hermida-Gómez T, Fuentes-Boquete I, Toro-Santos FJ, et al. Generation of osteoarthritis and healthy mesenchymal cell lines for research on regenerative medicine for osteoarthritis. Póster presentado en: OARSI 2018. World Congress of Osteoarthritis; 2018 Abr 26-29; Liverpool
[Purpose] Bone-marrow mesenchymal stem cells (BM-MSCs) are multipotent self-renewal adult cells with potential to regenerate the damaged tissues in degenerative diseases such as osteoarthritis (OA). Nevertheless, research require in vitro expansion of BM-MSCs, a process which eventually causes cell senescence. To overcome this problem cell lines can be used but, currently, BM-MSC lines available are scarce and present limitations regarding their differentiation capacities. For this reason, the aim of this study was to generate and characterize human BM-MSCs lines, derived from an OA patient and a healthy donor, with high chondrogenic and osteogenic capacities for their use in research on Regenerative Medicine for OA.