High relaxivity Mn2+-based MRI contrast agents
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High relaxivity Mn2+-based MRI contrast agentsAuthor(s)
Date
2014-12-16Citation
Regueiro-Figueroa, M., Rolla, G. A., Esteban-Gómez, D., de Blas, A., Rodríguez-Blas, T., Botta, M. and Platas-Iglesias, C. (2014), High Relaxivity Mn2+-Based MRI Contrast Agents. Chem. Eur. J., 20: 17300–17305.
Abstract
[Abstract] Stable Mn2+ mono- and binuclear complexes containing pentadentate 6,6′-((methylazanediyl)bis(methylene)) dipicolinic acid coordinating units give remarkably high relaxivities due to the presence of two inner-sphere water molecules. The mononuclear derivative binds human serum albumin (HSA) with an association constant of 3372 M−1, which results in the replacement of the coordinated water molecules by donor atoms of protein residues. The dinuclear analogue also binds HSA while leaving one of the Mn2+ centres exposed to the solvent with two coordinated water molecules. Thus, this complex shows remarkably high relaxivities upon protein binding (39.0 mM−1 s−1 per Mn, at 20 MHz and 37 °C).
Keywords
Contrast agents
Coordination compounds
Human serum albumin
Manganese
NMR imaging
Coordination compounds
Human serum albumin
Manganese
NMR imaging
Editor version
Rights
This is the peer reviewed version of the following article: Regueiro-Figueroa, M., Rolla, G. A., Esteban-Gómez, D., de Blas, A., Rodríguez-Blas, T., Botta, M. and Platas-Iglesias, C. (2014), High Relaxivity Mn2+-Based MRI Contrast Agents. Chem. Eur. J., 20: 17300–17305, which has been published in final form at https://doi.org/10.1002/chem.201404673. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
ISSN
0947-6539
1521-3765
1521-3765