Mostrar o rexistro simple do ítem
High relaxivity Mn2+-based MRI contrast agents
dc.contributor.author | Regueiro-Figueroa, Martín | |
dc.contributor.author | Rolla, Gabriele A. | |
dc.contributor.author | Esteban-Gómez, David | |
dc.contributor.author | Blas, Andrés de | |
dc.contributor.author | Rodríguez-Blas, Teresa | |
dc.contributor.author | Botta, Mauro | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.date.accessioned | 2017-10-27T12:54:11Z | |
dc.date.available | 2017-10-27T12:54:11Z | |
dc.date.issued | 2014-12-16 | |
dc.identifier.citation | Regueiro-Figueroa, M., Rolla, G. A., Esteban-Gómez, D., de Blas, A., Rodríguez-Blas, T., Botta, M. and Platas-Iglesias, C. (2014), High Relaxivity Mn2+-Based MRI Contrast Agents. Chem. Eur. J., 20: 17300–17305. | es_ES |
dc.identifier.issn | 0947-6539 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.uri | http://hdl.handle.net/2183/19647 | |
dc.description.abstract | [Abstract] Stable Mn2+ mono- and binuclear complexes containing pentadentate 6,6′-((methylazanediyl)bis(methylene)) dipicolinic acid coordinating units give remarkably high relaxivities due to the presence of two inner-sphere water molecules. The mononuclear derivative binds human serum albumin (HSA) with an association constant of 3372 M−1, which results in the replacement of the coordinated water molecules by donor atoms of protein residues. The dinuclear analogue also binds HSA while leaving one of the Mn2+ centres exposed to the solvent with two coordinated water molecules. Thus, this complex shows remarkably high relaxivities upon protein binding (39.0 mM−1 s−1 per Mn, at 20 MHz and 37 °C). | es_ES |
dc.description.sponsorship | Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; EM 2012/088 | es_ES |
dc.description.sponsorship | Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN 2012/011 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.uri | https://doi.org/10.1002/chem.201404673 | es_ES |
dc.rights | This is the peer reviewed version of the following article: Regueiro-Figueroa, M., Rolla, G. A., Esteban-Gómez, D., de Blas, A., Rodríguez-Blas, T., Botta, M. and Platas-Iglesias, C. (2014), High Relaxivity Mn2+-Based MRI Contrast Agents. Chem. Eur. J., 20: 17300–17305, which has been published in final form at https://doi.org/10.1002/chem.201404673. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | es_ES |
dc.subject | Contrast agents | es_ES |
dc.subject | Coordination compounds | es_ES |
dc.subject | Human serum albumin | es_ES |
dc.subject | Manganese | es_ES |
dc.subject | NMR imaging | es_ES |
dc.title | High relaxivity Mn2+-based MRI contrast agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Chemistry - A European Journal | es_ES |
UDC.volume | 20 | es_ES |
UDC.issue | 52 | es_ES |
UDC.startPage | 17300 | es_ES |
UDC.endPage | 17305 | es_ES |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-REACT! - Artigos [103]