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dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorSánchez-Flores, María
dc.contributor.authorMaseda, Ana
dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorMarcos Pérez, Diego
dc.contributor.authorLópez-Cortón Facal, Ana
dc.contributor.authorStrasser, Barbara
dc.contributor.authorFuchs, Dietmar
dc.contributor.authorLaffon, Blanca
dc.contributor.authorMillán-Calenti, José Carlos
dc.contributor.authorPasaro, Eduardo
dc.date.accessioned2017-10-11T10:16:04Z
dc.date.issued2017-05-19
dc.identifier.citationValdiglesias V, Sánchez-Flores M, Maseda A, et al. Immune biomarkers in older adults: role of physical activity. J Toxicol Environ Health A. 2017;80(13-15):605-620es_ES
dc.identifier.issn1528-7394
dc.identifier.urihttp://hdl.handle.net/2183/19589
dc.description3rd International Conference on Occupational & Environmental Toxicology/3rd Ibero-American Meeting on Toxicology and Environmental Health International, 21-23 June 2016, Porto, Portugales_ES
dc.description.abstract[Abstract] Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and aging or age-related outcomes, such as sarcopenia, depression, and neurodegenerative disorders. Physical activity is known to improve muscle function and to exert a number of benefits on older adult health, including reduced risk for heart and metabolic system chronic diseases. However, the positive influence of physical activity on the immune system has not been elucidated. In order to shed light on the role of physical activity in immune responses of older individuals, a number of immunological parameters comprising % lymphocyte subsets (CD3+, CD4+, CD8+, CD19+, and CD16+56+) and serum levels of neopterin and tryptophan metabolism products were evaluated in peripheral blood samples of older adults performing normal (N = 170) or reduced (N = 89) physical activity. In addition, the potential influence of other clinical and epidemiological factors was also considered. Results showed that subjects with reduced physical activity displayed significantly higher levels of CD4+/CD8+ ratio, kynurenine/tryptophan ratio, and serum neopterin, along with lower %CD19+ cells and tryptophan concentrations. Further, some immunological biomarkers were associated with cognitive impairment and functional status. These data contribute to reinforce the postulation that physical activity supports healthy aging, particularly by helping to protect the immunological system from aging-related changes.es_ES
dc.description.sponsorshipXunta de Galicia; ED431B 2016/013es_ES
dc.description.sponsorshipXunta de Galicia; GPC2014/082es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.relation.urihttp://dx.doi.org/10.1080/15287394.2017.1286898es_ES
dc.rightsThis is an accepted manuscript of an article published by Taylor & Francis in "Journal of Toxicology and Environmental Health, Part A", avaliable online at Taylor & Francis Onlinees_ES
dc.titleImmune biomarkers in older adults: role of physical activityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/embargoedAccesses_ES
dc.date.embargoEndDate2018-05-19es_ES
dc.date.embargoLift2018-05-19
UDC.journalTitleJournal of Toxicology and Environmental Health, Part Aes_ES
UDC.volume80es_ES
UDC.issue13-15es_ES
UDC.startPage605es_ES
UDC.endPage620es_ES


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