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Low serum levels of vitamin D are associated with progression of subclinical atherosclerotic vascular disease in peritoneal dialysis patients: a prospective, multicenter study
dc.contributor.author | Pérez-Fontán, Miguel | |
dc.contributor.author | Borrás Sans, Mercé | |
dc.contributor.author | Bajo Rubio, María Auxiliadora | |
dc.contributor.author | Rodríguez Carmona, Ana | |
dc.contributor.author | Betriu, Angels | |
dc.contributor.author | Valdivielso, José Manuel | |
dc.contributor.author | Fernández, Elvira | |
dc.date.accessioned | 2017-06-14T09:48:47Z | |
dc.date.available | 2017-06-14T09:48:47Z | |
dc.date.issued | 2017-02-25 | |
dc.identifier.citation | Pérez Fontán M, Borrás Sans M, Bajo Rubio MA, Rodríguez-Carmona A, Betriu A, Valdivielso JM, Fernández E. Low serum levels of vitamin D are associated with progression of subclinical atherosclerotic vascular disease in peritoneal dialysis patients: a prospective, multicenter study. Nephron. 2017;136(2):111-120 | es_ES |
dc.identifier.issn | 1660-8151 | |
dc.identifier.issn | 2235-3186 | |
dc.identifier.uri | http://hdl.handle.net/2183/19171 | |
dc.description.abstract | [Abstract] Background: The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated. Objectives and Method: Following a prospective, multicenter, observational design, we studied 237 patients who were treated with PD for ≥3 months, without any clinical background of cardiovascular (CV) disease. Our objectives were the following: (1) to investigate the prevalence of subclinical atherosclerosis, as compared to a control group of age- and sex-matched healthy individuals, and (2) to disclose PD technique-related predictors of progression of disease during a 24-month follow-up period. We used vascular ultrasound for characterization of subclinical atherosclerotic disease. Main Results: A total of 123 patients (51.9%) vs. 79 controls (33.5%) presented ≥1 carotid plaque, and 114 patients (48.3%) vs. 72 controls (30.5%) ≥1 femoral plaque, at baseline evaluation (p < 0.0005). Progression of disease, either in clinical or ultrasound (new plaques) terms, affected 62.6% of patients. Multivariate analysis identified age, carotid intima-media thickness, presence of ≥1 carotid plaque, and serum levels of 25OH vitamin D and C-reactive protein (CRP) at baseline as independent correlates of progression of atherosclerotic disease. On the contrary, PD technique-related variables did not show any association with this outcome. Conclusions: Atherosclerotic vascular disease is frequent among asymptomatic patients undergoing PD. Older age, pre-existent disease (assessed by vascular ultrasound), and serum levels of 25OH vitamin D and CRP are independent markers of the progression of this condition. These findings may contribute to improve identification of subpopulations with a high risk of CV events, deserving intensified measures of prevention. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Karger | es_ES |
dc.relation.uri | http://dx.doi.org/10.1159/000458418 | es_ES |
dc.subject | Peritoneal dialysis | es_ES |
dc.subject | Carotid atherosclerosis | es_ES |
dc.subject | Vitamin D | es_ES |
dc.title | Low serum levels of vitamin D are associated with progression of subclinical atherosclerotic vascular disease in peritoneal dialysis patients: a prospective, multicenter study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Nephron | es_ES |
UDC.volume | 136 | es_ES |
UDC.issue | 2 | es_ES |
UDC.startPage | 111 | es_ES |
UDC.endPage | 120 | es_ES |