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dc.contributor.authorPernas, Berta
dc.contributor.authorMena, Álvaro
dc.contributor.authorCañizares, Angelina
dc.contributor.authorGrandal, Marta
dc.contributor.authorCastro-Iglesias, Ángeles
dc.contributor.authorPértega-Díaz, Sonia
dc.contributor.authorPedreira, José D.
dc.contributor.authorPoveda, Eva
dc.date.accessioned2017-04-19T11:10:55Z
dc.date.available2017-04-19T11:10:55Z
dc.date.issued2015-03-16
dc.identifier.citationPernas B, Mena A, Cañizares A, et al. Trends on epidemiological, virological, and clinical features among newly diagnosed HIV-1 persons in Northwest Spain over the last 10 years. J Med Virol. 2015;87(8):1319-1326es_ES
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.urihttp://hdl.handle.net/2183/18403
dc.description.abstract[Abstract] To describe temporal trend and characteristics of newly HIV-diagnosed patients in a medical care area in Northwest Spain over the last 10 years. All newly diagnosed patients for HIV-infection from 2004 to 2013 at a reference medical care area in Northwest of Spain were identified. Epidemiological, virological, immunological, and clinical data, as well as HIV genotype and drug resistance information were recorded. A total of 565 newly HIV-diagnosed patients were identified. The number of new cases increased in the last 5 years (66 cases/year). Overall, 53.1% had a median CD4 counts < 350 cells/µl and 33.6% had an AIDS defining criteria. Non-B variants were found in 34.4% of patients being subtype F (25.8%) the most common non-B subtype. The rate of transmitted drug resistance (TDR) over the study period was 3.7%, but a decreased to 2.6% was observed in the last 5 years. The most prevalent TDR mutations were: T215 revertants (1.5%), K219QENR (1.2%), for NRTIs; K103N (1.9%), for NNRTIs; L90M (0.3%), for PIs. Overall, 73.2% of patients started antiretroviral treatment and 9.9% of patients died during follow-up. The number of newly HIV diagnosed patients increased since year 2009. There is a high prevalence of late diagnosis (53%) and 33% had an AIDS defining criteria. Interestingly, the most prevalent non-B subtype in our population was F (25.8%). These findings support the need to facilitate the access for HIV testing to reduce the rate of late HIV diagnosis, improve the clinical outcome and prevent HIV transmission.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; CP08/00214es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI10/02166es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; CM13/00328es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI13/02266es_ES
dc.language.isospaes_ES
dc.publisherWileyes_ES
dc.relation.urihttp://dx.doi.org/10.1002/jmv.24185es_ES
dc.rightsThis is the peer reviewed version of the article which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archivinges_ES
dc.subjectNewly HIV-diagnoseses_ES
dc.subjectLate diagnosises_ES
dc.subjectHIV-1 genetic subtypees_ES
dc.subjectTransmitted drug resistancees_ES
dc.titleTrends on epidemiological, virological, and clinical features among newly diagnosed HIV-1 persons in Northwest Spain over the last 10 yearses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleJournal of Medical Virologyes_ES
UDC.volume87es_ES
UDC.issue8es_ES
UDC.startPage1319es_ES
UDC.endPage1326es_ES


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