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dc.contributor.authorPernas, Berta
dc.contributor.authorGrandal, Marta
dc.contributor.authorPértega-Díaz, Sonia
dc.contributor.authorCañizares, Angelina
dc.contributor.authorCastro-Iglesias, Ángeles
dc.contributor.authorMena, Álvaro
dc.contributor.authorRodríguez-Osorio, Iria
dc.contributor.authorTabernilla, Andrés
dc.contributor.authorPedreira, José D.
dc.contributor.authorPoveda, Eva
dc.date.accessioned2017-04-06T09:24:00Z
dc.date.available2017-04-06T09:24:00Z
dc.date.issued2015-12-24
dc.identifier.citationPernas B, Grandal M, Pértega S, et al. Any impact of blips and low-level viraemia episodes among HIV-infected patients with sustained virological suppression on ART?. J Antimicrob Chemother. 2016;71(4):1051-1055es_ES
dc.identifier.issn0305-7453
dc.identifier.issn1460-2091
dc.identifier.urihttp://hdl.handle.net/2183/18387
dc.description.abstract[Abstract] Objectives. The objective of this study was to evaluate the prevalence of blips and risk of virological failure (VF) among HIV-infected patients with sustained virological suppression (HIV-RNA <50 copies/mL) on ART. Methods. Newly diagnosed (2004–13) HIV-infected patients with sustained virological suppression on ART (minimum follow-up of 3 months) were identified. Risk of VF was evaluated according to different plasma HIV-RNA quantification values based on the limits of quantification/detection of current commercial assays (20 copies/mL). Kaplan–Meier and Cox proportional hazards models were used to compare the cumulative incidence of VF. Results. A total of 565 newly diagnosed HIV-infected patients were identified: 453 started ART and 354 achieved virological suppression. Prevalence of blips (isolated HIV-RNA ranging from 50 to 200 copies/mL) and VF (HIV-RNA ≥50 copies/mL) was 22.7% and 8.8%, respectively (mean follow-up of 42 months). Multivariate analysis identified differences between HIV-RNA values as an independent predictor of VF (P = 0.008); risk of VF was higher for patients with blips [HR 2.500 (95% CI 0.524–11.926)] and for those with at least three consecutive detected, but not quantified, HIV-RNA determinations (HIV-RNA <20 copies/mL) [HR 3.813 (95% CI 0.675–21.535)]. Moreover, only HIV-infected patients with at least three consecutive detected, but not quantified, HIV-RNA determinations showed a higher probability of virological rebound with >200 copies/mL [33.7% at 24 and 60 months versus <5% for other HIV-RNA values; HR 6.943 (0.728–66.261), P = 0.092]. Conclusions. Blips are frequent (22.7%) among HIV-infected patients with sustained virological suppression on ART. HIV patients with blips and at least three consecutive detected, but not quantified, HIV-RNA determinations (<20 copies/mL) had a higher risk of VF. These findings highlight the relevance of maintaining HIV-RNA levels below the limits of quantification of current assays (<20 copies/mL).es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; CPII14/00014es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI10/02166es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI13/02266es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation.urihttps://doi.org/10.1093/jac/dkv433es_ES
dc.rightsThis is a pre-copyedited, author-produced version of an article accepted for publication in "Journal of Antimicrobial Chemotherapy" following peer review. The version of record is avaliable online at Oxford Academices_ES
dc.subjectHIVes_ES
dc.subjectFollow-upes_ES
dc.subjectPlasmaes_ES
dc.subjectViremiaes_ES
dc.subjectVirologyes_ES
dc.subjectBlood HIV RNAes_ES
dc.subjectHIV infectiones_ES
dc.titleAny impact of blips and low-level viraemia episodes among HIV-infected patients with sustained virological suppression on ART?es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleJournal of Antimicrobial Chemotherapyes_ES
UDC.volume71es_ES
UDC.issue4es_ES
UDC.startPage1051es_ES
UDC.endPage1055es_ES


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