Now showing items 6-10 of 24

    • Darunavir/cobicistat maintains the effectiveness of darunavir/ritonavir in HIV-infected patients under mono or dual therapy 

      Mena, Álvaro; Cid-Silva, Purificación; Dueñas, Carlos; Garcinuño, María Ángeles; Lorenzo, Juan Francisco; Margusino-Framiñán, Luis; Quiñones, Marina; Grande, Carmen; Rodríguez-Osorio, Iria; Castro-Iglesias, Ángeles (Taylor & Francis, 2019-01-03)
      [Abstract] OBJECTIVES: Darunavir/ritonavir (DRV/r) in mono or dual therapy has proven efficacy in selected patients. The aim of this study was to evaluate the efficacy of switching from DRV/r to DRV/cobicistat (DRV/c) in ...
    • High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4 

      Mariño, Zoe; Pascasio-Acevedo, Juan M.; Gallego, Adolfo; Diago, Moisés; Baliellas, Carme; Morillas, Rosa; Prieto, Martín; Moreno, José M.; Sánchez-Antolín, Gloria; Vergara, Mercedes; Forné, Monserrat; Fernández, Inmaculada; Castro-Iglesias, Ángeles; Pascual, Sonia; Gómez, Alexandra; Castells, Lluis; Montero, José L.; Crespo, Javier; Calleja, José L.; García-Samaniego, Javier; Carrión, José A.; Arencibia, Ana C.; Blasco, Alejandro; López-Núñez, Carmen; Sánchez-Ruano, Juan J.; Gea-Rodríguez, Francisco; Giráldez, Álvaro; Cabezas, Joaquín; Hontangas, Vanessa; Torras, Xavier; Castellote, José; Romero-Gómez, Manuel; Turnes, Juan; Artaza, Tomás de; Narváez, Isidro; Cuevas-Mons, Valentín; Forns, Xavier (Wiley, 2017-05-08)
      [Abstract] Background and Aims. Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real‐world clinical practice, showed high rates of sustained virological response (SVR) in non‐cirrhotic ...
    • Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication 

      Pernas, Berta; Rego-Pérez, Ignacio; Tabernilla, Andrés; Balboa Barreiro, Vanesa; Relaño, Sara; Grandal, Marta; Crespo, Manuel; Mena, Álvaro; Castro-Iglesias, Ángeles; Blanco García, Francisco J; Poveda, Eva (Oxford, 2017-08-31)
      [Abstract] Objectives. To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication. Methods. HIV-infected patients on follow-up at a ...
    • Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies 

      Grandal, Marta; Pernas, Berta; Tabernilla, Andrés; Mariño, Ana; Álvarez, Hortensia; Valcarce, Nieves; Mena, Álvaro; Castro-Iglesias, Ángeles; Pérez, Ana B.; Delgado, Manuel; Poveda, Eva (Wiley, 2018-02-10)
      [Abstract] The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV resistance at NS5A region is mainly focused on patients with ...
    • Cancer incidence in persons living with HIV 

      Meijide, Héctor; Mena, Álvaro; Rodríguez-Osorio, Iria; Castro-Iglesias, Ángeles; Poveda, Eva (Oxford University Press para Infectious Diseases Society of America, 2016-11-14)