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dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorMaseda, Ana
dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorPasaro, Eduardo
dc.contributor.authorMillán-Calenti, José Carlos
dc.contributor.authorLaffon, Blanca
dc.date.accessioned2017-01-20T12:25:19Z
dc.date.available2017-01-20T12:25:19Z
dc.date.issued2016-12-20
dc.identifier.citationValdiglesias V, Maseda A, Lorenzo-López L, Pásaro E, Millán-Calenti JC, Laffon B. Is salivary chromogranin A a valid psychological stress biomarker during sensory stimulation in people with advanced dementia?. J Alzheimers Dis. 2017;55(4):1509-1517es_ES
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.urihttp://hdl.handle.net/2183/17988
dc.description.abstract[Abstract] Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation environment (MSSE) in a Snoezelen room produce changes in sCgA in severely demented older patients, and to assess the possible existence of differences in sCgA levels between the two types of interventions. Older adults with severe dementia (n = 22) were randomly assigned to two intervention groups. They participated in MSSE or individualized music interventions in 30-min weekly sessions for 16 weeks. Levels of sCgA were evaluated before and after a session, or 30-min interval, at four different time points: before starting the trial, in the middle and end of the intervention period, and two months later. Comparison of sCgA values obtained after each session with those obtained before (or at the same hour in before trial and follow-up samplings) showed no significant differences either in the individualized music or in the MSSE group at any sampling time. Comparison between the two types of interventions, both before and after each session, in the four sampling times, did not produce any significant difference either. Furthermore, no significant correlation was obtained between agitation, anxiety, cognitive function, and dementia severity with sCgA levels. In conclusion, despite beneficial effects of both individualized music and MSSE interventions being previously reported on neuropsychiatric outcomes for older patients with dementia, sCgA seems to not be a good indicator of these benefits.es_ES
dc.description.sponsorshipXunta de Galicia; GPC2013-058es_ES
dc.description.sponsorshipXunta de Galicia; GPC2014/082es_ES
dc.language.isoenges_ES
dc.publisherIOS Presses_ES
dc.relation.urihttp://dx.doi.org/10.3233/JAD-160893es_ES
dc.rightsThe final publication is avaliable at IOS Press Content Libraryes_ES
dc.subjectChromogranin Aes_ES
dc.subjectDementiaes_ES
dc.subjectIndividualized musices_ES
dc.subjectMultisensory stimulationes_ES
dc.subjectOlder adultses_ES
dc.subjectSnoezelenes_ES
dc.titleIs salivary chromogranin A a valid psychological stress biomarker during sensory stimulation in people with advanced dementia?es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleJournal of Alzheimer’s Diseasees_ES
UDC.volume55es_ES
UDC.issue4es_ES
UDC.startPage1509es_ES
UDC.endPage1517es_ES


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