Mostrando ítems 1-10 de 48
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications
[Abstract] Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin ...
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)
[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome
[Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment. Objective. Taking the results of an earlier ...
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
[Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
Importance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjects
[Abstract] The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic ...
Adenoma hipofisiario no funcionante: estudio clínico y patológico
Treatment adherence to pegvisomant in patients with acromegaly in Spain: PEGASO study
[Abstract] PURPOSE: The burden of chronic daily subcutaneous administration of pegvisomant on adherence has not been previously studied. This study was aimed to determine the adherence to pegvisomant treatment in acromegaly ...
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
(Public Library of Science (PLoS), 2019-11-07)
[Abstract] Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; ...