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Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
(MDPI, 2020-05-28)
[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union
are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone
formation and are ...
Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients
(Nature Publishing Group, 2019-06-29)
[Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...
Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction
(Frontiers Media S.A., 2020-10-14)
[Abstract]
Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint
replacement remains the standard of care for knee OA patients, knee joint distraction
(KJD), which works by temporarily off-loading ...
Mesenchymal stem cell functionalization for enhanced therapeutic applications
(Mary Ann Liebert, 2019-02-14)
[Abstract] Culture expansion of MSCs has detrimental effects on various cell characteristics and attributes (e.g., phenotypic changes and senescence), which, in addition to inherent interdonor variability, negatively impact ...