Listar INIBIC-TCMR - Artigos por autor "Fafián Labora, Juan Antonio"
Mostrando ítems 1-13 de 13
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3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2
Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)[Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ... -
Biodistribution and immunogenicity of allogeneic mesenchymal stem cells in a rat model of intraarticular chondrocyte xenotransplantation
Marquina, Maribel; Collado, Javier A.; Pérez-Cruz, Magdiel; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J; Máñez, Rafael; Arufe, M.C.; Costa, Cristina (Frontiers, 2017-11-06)[Abstract] Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic ... -
Development of new non-viral systems for genetic modification of senescent cells
López-Seijas, Junquera; Miranda-Balbuena, Diego; Iglesias-Fente, Alba; Sacristán-Santos, Marta; Carballo-Pedrares, Natalia; Arufe, M.C.; Rey-Rico, Ana; Fafián Labora, Juan Antonio (Cell Press, 2023-03-20)[Abstract] Senescence is a process characterized by a prolonged irreversible cell-cycle arrest. The accumulation of senescent cells in tissues is related to aging and to the development of age-related diseases. Recently, ... -
Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles
Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Sangiao-Alvarellos, Susana; Monserrat, Lorenzo; Arntz, O.J.; Van de Loo, F.J.; Mateos, Jesús; Arufe, M.C. (Nature, 2017-03-06)[Abstract] Stem cells possess significant age-dependent differences in their immune-response profile. These differences were analysed by Next-Generation Sequencing of six age groups from bone marrow mesenchymal stem cells. ... -
Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ... -
High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome
Fafián Labora, Juan Antonio; Morente López, Miriam; De-Toro, Javier; Arufe, M.C. (MDPI, 2021-07-07)[Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ... -
Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential
Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Oreiro, Natividad; Sangiao-Alvarellos, Susana; Mateos, Jesús; Arufe, M.C. (Nature, 2015-11-19)[Abstract] Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age. Six age groups from bone ... -
Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their tole in ageing
Fafián Labora, Juan Antonio; Morente-López, Miriam; Sánchez-Dopico, María José; Arntz, O.J.; Van de Loo, F.J.; De-Toro, Javier; Arufe, M.C. (Springer Nature, 2020-01-03)[Abstract] Introduction: This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added. Methods: MSC-derived ... -
iTRAQ-Based Analysis of Progerin Expression Reveals Mitochondrial Dysfunction, Reactive Oxygen Species Accumulation and Altered Proteostasis
Mateos, Jesús; Landeira-Abia, Arancha; Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Lesende-Rodríguez, Iván; Fernández-Puente, Patricia; Fernández-Moreno, Mercedes; Delmiro, Aitor; Martín, Miguel A.; Blanco García, Francisco J; Arufe, M.C. (BioMed Central, 2015-06-12)[Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ... -
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
Mateos, Jesús; Fafián Labora, Juan Antonio; Morente-López, Miriam; Lesende-Rodríguez, Iván; Monserrat, Lorenzo; Ódena, María A.; Oliveira, Eliandre de; De-Toro, Javier; Arufe, M.C. (PLOS, 2018-10-31)[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ... -
NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
Fafián Labora, Juan Antonio; O'Loghlen, Ana (Wiley, 2021-06-29)[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ... -
Proteomic Applications in the Study of Human Mesenchymal Stem Cells
Mateos, Jesús; Arufe, M.C.; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J (Multidisciplinary Digital Publishing Institute, 2014-02-07)Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ... -
Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage
Fafián Labora, Juan Antonio; Rodríguez-Navarro, José Antonio; O’Loghlen, Ana (Elsevier, 2020-07-07)[Abstract] Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...