Listar INIBIC-TCMR - Artigos por autor "De-Toro, Javier"
Mostrando ítems 1-20 de 44
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3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2
Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)[Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ... -
A Comparative Study of Doppler Ultrasound Against Temporal Artery Biopsy in the Diagnosis of Giant Cell Arteritis
González Porto, Sara Alicia; Silva-Díaz, María T.; Reguera Arias, Ana; Pombo-Otero, Jorge; González Rodríguez, Alba; Valero Gasalla, Javier; De-Toro, Javier (Elsevier, 2020-08-13)[Abstract] Background. Giant cell arteritis (GCA) is a vasculitis that affects medium- and large-sized arteries. Temporal artery biopsy is the gold standard for diagnosis. In view of the high demand for temporal biopsies, ... -
A survey of anatomical items relevant to the practice of rheumatology: pelvis, lower extremity, and gait
Hernández-Díaz, Cristina; Álvarez-Nemegyei, José; Navarro-Zarza, José Eduardo; Villaseñor-Ovies, Pablo; Kalish, Robert A.; Canoso, Juan J.; Vargas, Angélica; Chiapas-Gasca, Karla; Biundo, Joseph J.; De-Toro, Javier; McGonagle, Dennis; Carette, Simon; Saavedra, Miguel Ángel (Springer, 2017-06-01)[Abstract] This study aimed to generate a minimum list of structural and functional anatomical items about the pelvis/hip, knee, ankle/foot, gait, and lower limb innervation, which are most relevant to the practice of ... -
A survey of anatomical items relevant to the practice of rheumatology: upper extremity, head, neck, spine, and general concepts
Villaseñor-Ovies, Pablo; Navarro-Zarza, José Eduardo; Saavedra, Miguel Ángel; Hernández-Díaz, Cristina; Canoso, Juan J.; Biundo, Joseph J.; Kalish, Robert A.; De-Toro, Javier; McGonagle, Dennis; Carette, Simon; Álvarez-Nemegyei, José (Springer, 2016-08-18)[Abstract] This study aimed to identify the anatomical items of the upper extremity and spine that are potentially relevant to the practice of rheumatology. Ten rheumatologists interested in clinical anatomy who published, ... -
Adherence to synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: results of the OBSERVAR study
Juan Mas, Antonio; Castañeda, Santos; Cantero Santamaría, José I.; Baquero, José L.; De-Toro, Javier (Elsevier, 2019-01-10)[Abstract] Background: Treatment compliance with disease-modifying antirheumatic drugs (DMARD) is essential to achieve the therapeutic goals in rheumatoid arthritis (RA). However, despite the need for good compliance, there ... -
Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
Arufe, M.C.; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-06-28)[Abstract] Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers ... -
Association between non-adherence behaviors, patients’ experience with healthcare and beliefs in medications: a survey of patients with different chronic conditions
Cea-Calvo, Luis; Marín-Jiménez, Ignacio; De-Toro, Javier; Fuster-RuizdeApodaca, María J.; Fernández, Gonzalo; Sánchez-Vega, Nuria; Orozco-Beltrán, Domingo (Taylor & Francis, 2019-10-15)[Abstract] Objective: The objective of the current work was to assess the frequency of non-adherence behaviors and potential association with patients' experience with healthcare and beliefs in medicines self-reported by ... -
Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects
Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muíños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-03-22)[Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ... -
CD105+-Mesenchymal Stem Cells Migrate into Osteoarthritis Joint: an Animal Model
Fernández-Pernas, Pablo; Rodríguez-Lesende, Iván; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (PLoS, 2017-11-30)[Abstract] Mesenchymal stem cells are being the focus of connective tissue technology and regenerative medicine, presenting a good choice cell source for improving old and well recognized techniques of cartilage defect ... -
Cell and Tissue Transplant Strategies for Joint Lesions
Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Bentham Open, 2008-07-11)[Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ... -
Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes
Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2010-07-21)[Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers. Subpopulations of human ... -
Clinical profile, level of affection and therapeutic management of patients with osteoarthritis in primary care: the spanish multicenter study EVALÚA
Castaño Carou, Ana Isabel; Pita-Fernández, Salvador; Pértega-Díaz, Sonia; De-Toro, Javier (Elsevier, 2015-04-16)[Abstract] Objective. To determine the clinical profile, degree of involvement and management in patients with knee, hip or hand osteoarthritis. Methods. Observational study (health centres from 14 autonomous regions, n ... -
Different associations of intentional and non-intentional non-adherence behaviors with patient experience with healthcare and patient beliefs in medications: a survey of patients with chronic conditions
Cea-Calvo, Luis; Marín-Jiménez, Ignacio; De-Toro, Javier; Fuster-RuizdeApodaca, María J.; Fernández, Gonzalo; Sánchez-Vega, Nuria; Orozco-Beltrán, Domingo (Dove Press, 2020-12-14)[Abstract] Purpose: To investigate relationships between intentional and non-intentional non-adherence behaviors and patient experience with healthcare and beliefs in medications. Patients and methods: This is a post ... -
Differentiation of Synovial CD-105+ Human Mesenchymal Stem Cells into Chondrocyte-like Cells through Spheroid Formation
Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2009-06-18)[Abstract] Mesenchymal stem cells (MSCs) have the capacity to differentiate into several cell lineages, some of which can generate bone, cartilage, or adipose tissue. The presence of MSCs in the synovial membrane was ... -
Exploring the remission concept in rheumatoid arthritis with patients and rheumatologists: time for a new approach?
Acebes, Carlos; Andreu, José Luis; Balsa, Alejandro; Batlle, Enrique; De-Toro, Javier; García Llorente, Francisco; Hernández, María Victoria; Fernández-Gutiérrez, Benjamín; Hidalgo-Calleja, Cristina; Mayordomo, Lucía; Naredo, Esperanza; Narváez, Francisco Javier; Ortiz, Ana M.; Pablos, José Luis; Pérez-Sandoval, Trinidad; Rodríguez-Lozano, Carlos; Sánchez-Pernaute, Olga; Usón, Jacqueline; Negrón, José Bernardo; Loza, Estíbaliz; Carmona, Loreto; Gómez Castro, Susana; Montoro Álvarez, María (Clinical and Experimental Rheumatology, 2017-09)[Abstract] Objectives: To explore the remission concept in rheumatoid arthritis (RA) and to compare remission definitions and related concepts between rheumatologists and patients with the purpose of identifying ... -
Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts
Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)[Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ... -
Healthcare experience among patients with type 2 diabetes: A cross-sectional survey using the IEXPAC tool
Orozco-Beltrán, Domingo; Artola-Menéndez, Sara; Hormigo-Pozo, Antonio; Cararach-Salami, Daniel; Alonso-Jerez, José Luis; Álvaro-Grande, Epifanio; Villalibre-Arias, Covadonga; De-Toro, Javier; Galindo-Puerto, María José; Marín-Jiménez, Ignacio; Gómez-García, Antón; Ledesma-Rodríguez, Rocío; Fernández, Gonzalo; Ferreira de Campos, Karine (Wiley, 2021-02-15)[Abstract] Aim: To assess the experience with health care among patients with type 2 diabetes (T2DM) and to evaluate patients' demographic variables and healthcare-related characteristics which may affect their ... -
Healthcare experience and their relationship with demographic, disease and healthcare-related variables: a cross-sectional survey of patients with chronic diseases using the IEXPAC scale.
Orozco-Beltrán, Domingo; De-Toro, Javier; Galindo, María J.; Marín-Jiménez, Ignacio; Casellas, Francesc; Fuster-RuizdeApodaca, María J.; García-Vivar, María L.; Hormigo-Pozo, Antonio; Guilabert, Mercedes; Sánchez-Vega, Nuria; Fernández, Gonzalo; Cea-Calvo, Luis (Springer, 2018-11-15)[Abstract] BACKGROUND: Patient experience is acknowledged as a principal aspect of quality healthcare delivery, and it has implications with regard to outcomes. OBJECTIVES: Our objective was to evaluate the healthcare ... -
High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome
Fafián Labora, Juan Antonio; Morente López, Miriam; De-Toro, Javier; Arufe, M.C. (MDPI, 2021-07-07)[Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ... -
Human amniotic membrane as an alternative source of stem cells for regenerative medicine
Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Cicione, Claudia; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2011-02-19)[Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...