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The hCOMET Project: International Database Comparison of Results with the Comet Assay in Human Biomonitoring. Baseline Frequency of DNA Damage and Effect of Main Confounders
(2021)
[Abstract] The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification ...
Epigenetics Is Implicated in the Basis of Gender Incongruence: An Epigenome-Wide Association Analysis
(2021)
[Abstract] Introduction: The main objective was to carry out a global DNA methylation analysis in a population with gender incongruence before gender-affirming hormone treatment (GAHT), in comparison to a cisgender ...
“Micronuclei and Disease” special issue: Aims, scope, and synthesis of outcomes
(2021)
[Abastract] The purpose of the “Micronuclei and Disease” special issue (SI) is to: (i) Determine the level of evidence for association of micronuclei (MN), a biomarker of numerical and structural chromosomal aberrations, ...
DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death
(2021)
[Abstract] The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, ...
The Effects of Testosterone on the Brain of Transgender Men
(Mary Ann Liebert, 2021)
[Abstract] Transgender men (TM) experience an incongruence between the female sex assigned when they were born
and their self-perceived male identity. Some TM seek for a gender affirming hormone treatment (GAHT) to induce
a ...
Salivary Leucocytes as In Vitro Model to Evaluate Nanoparticle-Induced DNA Damage
(MDPI, 2021-07-27)
[Abstract] Metal oxide nanoparticles (NPs) have a wide variety of applications in many consumer products and biomedical practices. As a result, human exposure to these nanomaterials is highly frequent, becoming an issue ...
Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO2 Nanoparticles on SH-SY5Y Cells
(2021)
[Abstract] Standard toxicity tests might not be fully adequate for evaluating nanomaterials since
their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block
micronucleus (CBMN) ...
Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
(2021)
[Abstract] Ageing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with ...
Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence
(2021)
[Abstract] Introduction
Brain sexual differentiation results from the effects of sex steroids on the developing brain. The presumptive route for brain masculinization is the direct induction of gene expression via activation ...