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DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death

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Bonassi_Stefano_2021_DNA_damage_in_circulating_leukocytes.pdf (1.089Mb)
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http://hdl.handle.net/2183/29145
Atribución 4.0 Internacional
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  • Investigación (FEDU) [938]
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Título
DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death
Autor(es)
Bonassi, Stefano
Ceppi, Marcello
Møller, Peter
Azqueta, Amaya
Milić, Mirta
Neri, Monica
Brunborg, Gunnar
Godschalk, Roger
Koppen, Gudrun
Langie, Sabine
Teixeira, Joao
Bruzzone, Marco
Da Silva, Juliana
Benedetti, Danieli
Cavallo, Delia
Ursini, Cinzia Lucia
Giovannelli, Lisa
Moretti, Silvia
Riso, Patrizia
Del Bo’, Cristian
Russo, Patrizia
Dobrzyńska, Malgorzata
Goroshinskaya, Irina A.
Surikova, Ekaterina
Staruchova, Marta
Barančoková, Magdaléna
Volkovova, Katarina
Kažimírová, Alena
Smolkova, Bozena
Laffon, Blanca
Valdiglesias, Vanessa
Pastor, Susana
Marcos, Ricard
Hernández, Alba
Gajski, Goran
Spremo-Potparević, Biljana
Živković, Lada
Boutet-Robinet, Elisa
Perdry, Hervé
Lebailly, Pierre
Pérez, Carlos L.
Başaran, Nurşen
Nemeth, Zsuzsanna
Sáfár, Anna
Dusinska, Maria
Collins, Andrew
Data
2021
Cita bibliográfica
Bonassi, S., Ceppi, M., Møller, P. et al. DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Sci Rep 11, 16793 (2021). https://doi.org/10.1038/s41598-021-95976-7
Resumo
[Abstract] The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.
Descrición
Author Correction: https://doi.org/10.1038/s41598-021-98620-6. The original version of this Article contained errors: The spelling of the author Monica Neri was incorrectly given as Neri Monica; Additionally, Affiliation 39 was incorrectly given as ‘National Institute of Health, Lisbon, Portugal’, the correct affiliation is listed below: National Institute of Health Doutor Ricardo Jorge, Porto, Portugal. The original Article has been corrected.
Versión do editor
https://doi.org/10.1038/s41598-021-95976-7
Dereitos
Atribución 4.0 Internacional
Recurso relacionado
https://doi.org/10.1038/s41598-021-98620-6

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