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Involvement of mitochondrial dysfunction in the inflammatory response in human mesothelial cells from peritoneal dialysis effluent
(MDPI, 2022-11-04)
[Abstract] Recent studies have related mitochondrial impairment with peritoneal membrane damage during peritoneal dialysis (PD) therapy. Here, we assessed the involvement of mitochondrial dysfunction in the inflammatory ...
MiR-19 family impairs adipogenesis by the downregulation of the PPARγ transcriptional network
(MDPI, 2022-12-13)
[Abstract] microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families ...
Thyroid function alteration in obesity and the effect of bariatric surgery
(MDPI, 2022-02-28)
[Abstract] The most common endocrine disease in obesity is hypothyroidism and secondary endocrine alterations, including abnormal thyroid function, are frequent in obesity. It is unclear whether impaired thyroid function ...
Long-term trends in the incidence of peritoneal dialysis-related peritonitis disclose an increasing relevance of streptococcal infections: a longitudinal study
(Public Library of Science (PLoS), 2020-12-21)
[Abstract}
Background.
The selective impact of strategies for prevention of PD-related peritonitis (PDrP) may have modified, in the long term, the causal spectrum, clinical presentation and outcomes of these ...
Evaluation of thyroid hormone replacement dosing in morbidly obese hypothyroid patients after bariatric surgery-induced weight loss
(MDPI, 2021-08-19)
[Abstract] The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of ...
Does prior abdominal surgery influence peritoneal transport characteristics or technique survival of peritoneal dialysis patients?
(Karger, 2020-10-22)
[Abstract] Introduction: Prior abdominal surgery may result in peritoneal membrane adhesions and fibrosis, compromising the success of peritoneal dialysis (PD). The impact of this factor on peritoneal membrane function and ...
Metabolic recovery after weight loss surgery is reflected in serum microRNAs
(BMJ Publishing Group, 2020-10-01)
[Abstract]
INTRODUCTION: Bariatric surgery offers the most effective treatment for obesity, ameliorating or even reverting associated metabolic disorders, such as type 2 diabetes. We sought to determine the effects of ...
Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation
(MDPI, 2020-08-12)
[Abstract] Endocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like growth factor-1 (IGF-1) values are ...
Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly
(Springer, 2020-07-28)
[Abstract]
Purpose. Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly ...
Cost-effectiveness analysis of second-line pharmacological treatment of acromegaly in Spain
(Taylor&Francis, 2020-05-06)
[Abstract]
Objective: To estimate the cost-effectiveness of second-line pharmacological treatments in patients
with acromegaly resistant to first-generation somatostatin analogues (FG SSA) from the Spanish
National ...