ListarGrupo de investigación en Terapia Celular e Medicina Rexenerativa (TCMR) por tema "Inflammation"

Mostrando ítems 1-6 de 6

    • Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes 

      Burguera, Elena F.; Vela-Anero, Á.; Magalhaes, J.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Elsevier, 2014-07)
      [Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...

    • Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida-Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Vaamonde-García, Carlos; Díaz-Prado, Silvia (The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
      [Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...

    • Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Relevance of the extraction stage on the anti-inflammatory action of fucoidans 

      Flórez-Fernández, Noelia; Vaamonde-García, Carlos; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Lamas-Vázquez, María J.; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2023-03-01)
      [Abstract] The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining ...

    • The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint 

      Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-12)
      [Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...

    • The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis 

      Vaamonde-García, Carlos; Courties, Alice; Pigenet, Audrey; Laiguillon, Marie-Charlotte; Sautet, Alain; Houard, Xavier; Kerdine-Römer, Saadia; Meijide-Faílde, Rosa; Berenbaum, Francis; Sellam, Jérémie (American Society for Biochemistry and Molecular Biology, 2017-07-06)
      [Asbtract] Epidemiological findings support the hypothesis that type 2 diabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA). Moreover, OA cartilage from patients with T2DM exhibits a greater response to ...