Double-blind, randomized, placebo controlled trial on the effect of 10 days low-frequency rTMS over the vertex on sleep in Parkinson’s disease
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Double-blind, randomized, placebo controlled trial on the effect of 10 days low-frequency rTMS over the vertex on sleep in Parkinson’s diseaseDate
2010-07-31Citation
Arias P, Vivas J, Grieve KL, Cudeiro J. Double-blind, randomized, placebo controlled trial on the effect of 10 days low-frequency rTMS over the vertex on sleep in Parkinson’s disease. Sleep Med. 2010;11:759-65.
Abstract
[Abstract] Objective: A recent report indicates repetitive transcranial magnetic stimulation (rTMS) improves sleep
in Parkinson’s disease (PD). The aim of this work is to evaluate the effect of 10 days rTMS on sleep parameters
in PD patients.
Methods: Double-blind, placebo-controlled design. Eighteen idiopathic PD patients completed the study.
Sleep parameters were evaluated through actigraphy and the Parkinson’s Disease Sleep Scale (PDSS),
along with depression (Hamilton Depression Rating Scale, HDS), and the Unified Parkinson’s Disease Rating
Scale (UPDRS). Evaluations were carried out before treatment with rTMS (pre-evaluation, PRE), after
the rTMS treatment programme (post-evaluation, POST), and one week after POST (POST-2). Nine PD
patients received real rTMS and the other 9 received sham rTMS daily for 10 days, (100 pulses at 1 Hz)
applied with a large circular coil over the vertex.
Results: Stimulation had no effect over actigraphic variables. Conversely PDSS, HDS, and UPDRS were significantly
improved by the stimulation. Notably, however, these changes were found equally in groups
receiving real or sham stimulation.
Conclusions: rTMS, using our protocol, has no therapeutic value on the sleep of PD patients, when compared
to appropriate sham controls. Future works assessing the possible therapeutic role of rTMS on sleep
in PD should control the effect of placebo.
Keywords
Parkinson
Sleep
Repetitive transcranial magnetic stimulation (rTMS)
Actigraphy
Depression
Therapy
Sleep
Repetitive transcranial magnetic stimulation (rTMS)
Actigraphy
Depression
Therapy
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-BY-NC-ND 4.0)