ListarGrupo de Arquitectura de Computadores (GAC) por tema "Bioinformatics"

Mostrando ítems 1-13 de 13

    • bioScience: A new python science library for high-performance computing bioinformatics analytics 

      López-Fernández, Aurelio; Gómez-Vela, Francisco A.; González-Domínguez, Jorge; Bidare-Divakarachari, Parameshachari (Elsevier Ltd, 2024)
      [Abstract]: BioScience is an advanced Python library designed to satisfy the growing data analysis needs in the field of bioinformatics by leveraging High-Performance Computing (HPC). This library encompasses a vast multitude ...

    • Fast search of third-order epistatic interactions on CPU and GPU clusters 

      Ponte-Fernández, Christian; González-Domínguez, Jorge; Martín, María J. (Sage Publications Ltd., 2019-05-27)
      [Abstract] Genome-Wide Association Studies (GWASs), analyses that try to find a link between a given phenotype (such as a disease) and genetic markers, have been growing in popularity in the recent years. Relations between ...

    • High-speed exhaustive 3-locus interaction epistasis analysis on FPGAs 

      Kässens, Jan Christian; Wienbrandt, Lars; González-Domínguez, Jorge; Schmidt, Bertil; Schimmler, Manfred (Elsevier B.V., 2015-07)
      [Abstract]: Epistasis, the interaction between genes, has become a major topic in molecular and quantitative genetics. It is believed that these interactions play a significant role in genetic variations causing complex ...

    • Hybrid CPU/GPU Acceleration of Detection of 2-SNP Epistatic Interactions in GWAS 

      González-Domínguez, Jorge; Schmidt, Bertil; Kässens, Jan Christian; Wienbrandt, Lars (Springer, 2014-08)
      [Abstract] High-throughput genotyping technologies allow the collection of up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as 2-SNP interactions, ...

    • Large-scale genome-wide association studies on a GPU cluster using a CUDA-accelerated PGAS programming model 

      González-Domínguez, Jorge; Kässens, Jan Christian; Wienbrandt, Lars; Schmidt, Bertil (Sage Publications Ltd., 2015)
      [Abstract] Detecting epistasis, such as 2-SNP interactions, in genome-wide association studies (GWAS) is an important but time consuming operation. Consequently, GPUs have already been used to accelerate these studies, ...

    • MPI-dot2dot: A Parallel Tool to Find DNA Tandem Repeats on Multicore Clusters 

      González-Domínguez, Jorge; Martín Martínez, José Manuel; Expósito, Roberto R. (Springer, 2022)
      [Abstract] Tandem Repeats (TRs) are segments that occur several times in a DNA sequence, and each copy is adjacent to other. In the last few years, TRs have gained significant attention as they are thought to be related ...

    • Multimethod Optimization for Reverse Engineering of Complex Biological Networks 

      González, Patricia; Penas, David R.; Pardo, Xoán C.; Banga, Julio R.; Doallo, Ramón (Association for Computing Machinery, 2018-09)
      [Abstract] Optimization problems appears in different areas of science and engineering. This paper considers the general problem of reverse engineering in computational biology by means of mixed-integer nonlinear dynamic ...

    • Parallel and Scalable Short-Read Alignment on Multi-Core Clusters Using UPC++ 

      Liu, Yongchao; Schmidt, Bertil; González-Domínguez, Jorge (Johannes Gutenberg University Mainz, 2016)
      [Abstract]: The growth of next-generation sequencing (NGS) datasets poses a challenge to the alignment of reads to reference genomes in terms of alignment quality and execution speed. Some available aligners have been shown ...

    • Parallelizing Epistasis Detection in GWAS on FPGA and GPU-Accelerated Computing Systems 

      González-Domínguez, Jorge; Wienbrandt, Lars; Kässens, Jan Christian; Ellinghaus, David; Schimmler, Manfred; Schmidt, Bertil (Institute of Electrical and Electronics Engineers, 2015)
      [Abstract] High-throughput genotyping technologies (such as SNP-arrays) allow the rapid collection of up to a few million genetic markers of an individual. Detecting epistasis (based on 2-SNP interactions) in Genome-Wide ...

    • parSRA: A framework for the parallel execution of short read aligners on compute clusters 

      González-Domínguez, Jorge; Hundt, Christian; Schmidt, Bertil (2018)
      [Abstract]: The growth of next generation sequencing datasets poses as a challenge to the alignment of reads to reference genomes in terms of both accuracy and speed. In this work we present parSRA, a parallel framework ...

    • Performance Optimization of a Parallel Error Correction Tool 

      Martínez-Sánchez, Marco; Expósito, Roberto R.; Touriño, Juan (MDPI, 2021)
      [Abstract] Due to the continuous development in the field of Next Generation Sequencing (NGS) technologies that have allowed researchers to take advantage of greater genetic samples in less time, it is a matter of relevance ...

    • pRIblast: A highly efficient parallel application for comprehensive lncRNA–RNA interaction prediction 

      Amatria Barral, Iñaki; González-Domínguez, Jorge; Touriño, Juan (Elsevier, 2023-01)
      [Abstract]: Long non-coding RNAs (lncRNAs) play a key role in several biological processes and scientists are constantly trying to come up with new strategies to elucidate their functions. One common approach to characterize ...

    • SeQual: Big Data Tool to Perform Quality Control and Data Preprocessing of Large NGS Datasets 

      Expósito, Roberto R.; Galego Torreiro, Roi; González-Domínguez, Jorge (Institute of Electrical and Electronics Engineers, 2020-08-07)
      [Abstract] This paper presents SeQual, a scalable tool to efficiently perform quality control of large genomic datasets. Our tool currently supports more than 30 different operations (e.g., filtering, trimming, formatting) ...