Listar por autor "Lesende-Rodríguez, Iván"
Mostrando ítems 1-7 de 7
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3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2
Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)[Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ... -
Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles
Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Sangiao-Alvarellos, Susana; Monserrat, Lorenzo; Arntz, O.J.; Van de Loo, F.J.; Mateos, Jesús; Arufe, M.C. (Nature, 2017-03-06)[Abstract] Stem cells possess significant age-dependent differences in their immune-response profile. These differences were analysed by Next-Generation Sequencing of six age groups from bone marrow mesenchymal stem cells. ... -
iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
Mateos, Jesús; Landeira-Abia, Arancha; Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Lesende-Rodríguez, Iván; Fernández-Puente, Patricia; Fernández-Moreno, Mercedes; Delmiro, Aitor; Martín, Miguel A.; Blanco García, Francisco J; Arufe, M.C. (BioMed Central, 2015-06-12)[Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ... -
Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress
Mateos, Jesús; Fuente, Alexandre de la; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Arufe, M.C.; Blanco García, Francisco J (Elsevier, 2013-07-26)[Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ... -
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
Mateos, Jesús; Fafián Labora, Juan Antonio; Morente-López, Miriam; Lesende-Rodríguez, Iván; Monserrat, Lorenzo; Ódena, María A.; Oliveira, Eliandre de; De-Toro, Javier; Arufe, M.C. (PLOS, 2018-10-31)[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ... -
Optimización de la técnica de utrasecuenciación para el estudio de miocardiopatías congénitas humanas
Lesende-Rodríguez, Iván (2017)[Resumen] Dada la importancia que está adquiriendo la secuenciación de ácidos nucleicos, no sólo en el ámbito del diagnóstico genético, sino en el de la medicina en general. Desde el año 2005, se ha venido desarrollando ... -
Proteome analysis during chondrocyte differentiation in a new chondrogenesis model using human umbilical cord stroma mesenchymal stem cells
Fuente, Alexandre de la; Mateos, Jesús; Lesende-Rodríguez, Iván; Calamia, Valentina; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Arufe, M.C.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology, 2011-10-17)[Abstract] Umbilical cord stroma mesenchymal stem cells were differentiated toward chondrocyte-like cells using a new in vitro model that consists of the random formation of spheroids in a medium supplemented with fetal ...