Now showing items 1-9 of 9

    • 3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2 

      Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)
      [Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ...
    • Biodistribution and Immunogenicity of Allogeneic Mesenchymal Stem Cells in a Rat Model of Intraarticular Chondrocyte Xenotransplantation 

      Marquina, Maribel; Collado, Javier A.; Pérez-Cruz, Magdiel; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J; Máñez, Rafael; Arufe, M.C.; Costa, Cristina (Frontiers, 2017-11-06)
      [Abstract] Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic ...
    • CD105+-Mesenchymal Stem Cells Migrate into Osteoarthritis Joint: an Animal Model 

      Fernández-Pernas, Pablo; Rodríguez-Lesende, Iván; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (PLoS, 2017-11-30)
      [Abstract] Mesenchymal stem cells are being the focus of connective tissue technology and regenerative medicine, presenting a good choice cell source for improving old and well recognized techniques of cartilage defect ...
    • Effect of Age on Pro-Inflammatory miRNAs Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles 

      Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Sangiao-Alvarellos, Susana; Monserrat, Lorenzo; Arntz, O.J.; Van de Loo, F.J.; Mateos, Jesús; Arufe, M.C. (Nature, 2017-03-06)
      [Abstract] Stem cells possess significant age-dependent differences in their immune-response profile. These differences were analysed by Next-Generation Sequencing of six age groups from bone marrow mesenchymal stem cells. ...
    • Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential 

      Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Oreiro, Natividad; Sangiao-Alvarellos, Susana; Mateos, Jesús; Arufe, M.C. (Nature, 2015-11-19)
      [Abstract] Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age. Six age groups from bone ...
    • iTRAQ-Based Analysis of Progerin Expression Reveals Mitochondrial Dysfunction, Reactive Oxygen Species Accumulation and Altered Proteostasis 

      Mateos, Jesús; Landeira-Abia, Arancha; Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Lesende-Rodríguez, Iván; Fernández-Puente, Patricia; Fernández-Moreno, Mercedes; Delmiro, Aitor; Martín, Miguel A.; Blanco García, Francisco J; Arufe, M.C. (BioMed Central, 2015-06-12)
      [Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ...
    • Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in their Chondrogenic Potential and Imbalance in their Response to Oxidative Stress 

      Mateos, Jesús; Fuente, Alexandre de la; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Arufe, M.C.; Blanco García, Francisco J (Elsevier, 2013-07-26)
      [Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ...
    • Mesenchymal stromal cells for articular cartilage repair: preclinical studies 

      Fernández-Pernas, Pablo; Barrachina, Laura; Marquina, Maribel; Rodellar, C.; Arufe, M.C.; Costa, Cristina (AO Research Institute Davos (ARI), 2020-08-26)
      [Abstract] Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ...
    • Proteomic Applications in the Study of Human Mesenchymal Stem Cells 

      Mateos, Jesús; Arufe, M.C.; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J (Multidisciplinary Digital Publishing Institute, 2014-02-07)
      Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ...