Now showing items 1-17 of 17

    • Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue 

      Fernández Caggiano, Mariana; Prysyazhna, Oleksandra; Barallobre-Barreiro, Javier; Calviño Santos, Ramón; Aldama López, Guillermo; Crespo-Leiro, María Generosa; Eaton, Philip; Doménech, Nieves (American Society for Biochemistry and Molecular Biology, 2016-01-01)
    • Cardiac Protection Induced by Urocortin-2 Enables the Regulation of Apoptosis and Fibrosis After Ischemia and Reperfusion Involving miR-29a Modulation 

      Mayoral-González, Isabel; Calderón-Sánchez, Eva M.; Galeano-Otero, Isabel; Martín-Bórnez, Marta; Gutiérrez-Carretero, Encarnación; Fernández-Velasco, María; Doménech, Nieves; Crespo-Leiro, María Generosa; Gómez, Ana María; Ordoñez-Fernández, Antonio; Hmadcha, Abdelkrim; Smani, Tarik (Elsevier, 2022-01-28)
      [Abstract] Urocortin-2 (Ucn-2) has demonstrated cardioprotective actions against myocardial ischemia-reperfusion (I/R) injuries. Herein, we explored the protective role of Ucn-2 through microRNAs (miRNAs) post-transcriptional ...
    • Circulating Galectin-3 Following Heart Transplant: Long-term Dynamics and Prognostic Value 

      Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Bayés-Genís, Antoni; Doménech, Nieves; Moreda-Santamaría, Lucía; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Solla-Buceta, Miguel; Estévez-Cid, Francisco; Cuenca-Castillo, José J.; Pombo-Otero, Jorge; Grille-Cancela, Zulaika; Blanco-Canosa, Paula; Muñiz, Javier; Vázquez-Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2018-11-23)
      [Abstract] Introduction and objectives: Circulating galectin-3 (Gal-3) is elevated and significantly correlates with all-cause and cardiovascular mortality in patients with heart failure. However, the relationship between ...
    • Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling 

      Barallobre-Barreiro, Javier; Radovits, Tamás; Fava, Marika; Mayr, Ursula; Lin, Wen-Yu; Ermolaeva, Elizaveta; Martínez-López, Diego; Lindberg, Eric L.; Duregotti, Elisa; Daróczi, László; Hasman, Maria; Schmidt, Lukas E.; Singh, Bhawana; Lu, Ruifang; Baig, Ferheen; Siedlar, Aleksandra Malgorzata; Cuello, Friederike; Catiborg, Norman; Theofilatos, Konstantinos; Shah, Ajay M.; Crespo-Leiro, María Generosa; Doménech, Nieves; Hübner, Norbert; Merkely, Béla; Mayr, Manuel (American Heart Association, 2021-11-22)
      [Abstract] Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase ...
    • Genomic analysis of a novel pathogenic variant in the gene LMNA associated with cardiac laminopathies found in Ecuadorian siblings: A case report 

      Doménech, Nieves; Guevara-Ramírez, Patricia; Cadena-Ullauri, Santiago; Ibarra-Castillo, Rita; Laso-Bayas, José Luis; Paz-Cruz, Elius; Tamayo-Trujillo, Rafael; Ruiz-Pozo, Viviana A.; Ibarra Rodríguez, Adriana Alexandra; Zambrano, Ana Karina (Frontiers, 2023-03)
      [Abstract] Introduction: Cardiac laminopathies are caused by mutations in the LMNA gene and include a wide range of clinical manifestations involving electrical and mechanical changes in cardiomyocytes. In Ecuador, ...
    • Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation 

      Suárez-Fuentetaja, Natalia; Doménech, Nieves; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Barge-Caballero, Eduardo; Grille Cancela, Zulaika; Pombo-Otero, Jorge; Muñiz, Javier; Castro-Beiras, Alfonso; Crespo-Leiro, María Generosa (Elsevier, 2012-11-10)
      [Abstract] Background. The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been postulated that indirect determination of IDO ...
    • Intraneural IFG-1 in cryopreserved nerve isografts increase neural regeneration and functional recovery in the rat sciatic nerve 

      González Porto, Sara Alicia; Doménech, Nieves; Blanco García, Francisco J; Centeno, Alberto; Rivadulla, Casto; Álvarez Jorge, Álvaro; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Oxford, 2018-07-27)
      [Abstract] Background: Insulin-like growth factor 1 (IGF-1) was found to stimulate Schwann cell mitosis. Exogenous IGF-1 may improve nerve regeneration after cryopreservation. Objective: To evaulate the effect of ...
    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...
    • Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (PLoS, 2012-08-28)
      [Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...
    • Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy 

      Fernández-Caggiano, Mariana; Kamynina, Alisa; Francois, Asvi A.; Prysyazhna, Oleksandra; Eykyn, Thomas R.; Krasemann, Susanne; Crespo-Leiro, María Generosa; García-Vieites, M.; Bianchi, Katiuscia; Morales, Valle; Doménech, Nieves; Eaton, Philip (Springer Nature, 2020-10-26)
      [Abstract] Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates ...
    • Reduced mitochondrial pyruvate carrier expression in hearts with heart failure and reduced ejection fraction patients: ischemic vs. non-ischemic origin 

      López-Vázquez, Paula; Fernández-Caggiano, Mariana; Barge-Caballero, Eduardo; Barge-Caballero, Gonzalo; Couto-Mallón, David; Grille-Cancela, Zulaika; Blanco-Canosa, Paula; Paniagua-Martín, María J.; Enríquez-Vázquez, Daniel; Vázquez-Rodríguez, José M.; Doménech, Nieves; Crespo-Leiro, María Generosa (Frontiers, 2024-03-08)
      [Abstract] Introduction and objectives: Mitochondrial pyruvate carrier (MPC) mediates the entry of pyruvate into mitochondria, determining whether pyruvate is incorporated into the Krebs cycle or metabolized in the cytosol. ...
    • Role of NOD1 in heart failure progression via regulation of Ca2+ handling 

      Val-Blasco, Almudena; Piedras, María José; Ruiz-Hurtado, Gema; Suárez-Fuentetaja, Natalia; Prieto, Patricia; González-Ramos, Silvia; Gómez-Hurtado, Nieves; Delgado, Carmen; Pereira, Laetitia; Benito, Gemma; Zaragoza, Carlos; Doménech, Nieves; Crespo-Leiro, María Generosa; Vázquez-Echeverri, Daniel; Núñez, Gabriel; López-Collazo, Eduardo; Boscá, Lisardo; Fernández-Velasco, María (Elsevier para American College of Cardiology Foundation, 2017-01-23)
    • SERCA2a protein levels are unaltered in human heart failure 

      Ragone, Isabella; Barallobre-Barreiro, Javier; Takov, Kaloyan; Theofilatos, Konstantinos; Yin, Xiaoke; Schmidt, Lukas Emanuel; Doménech, Nieves; Crespo-Leiro, María Generosa; van der Voorn, Stephanie M.; Vink, Aryan; van Veen, Toon A.B.; Bödör, Csaba; Merkely, Béla; Radovits, Tamás; Mayr, Manuel (American Heart Association (AHA), 2023-08-14)
    • Serum levels of anti-alphaGalactosyl antibodies predict survival and peritoneal dialysis-related enteric peritonitis rates in patients undergoing renal replacement therapy 

      Pérez-Fontán, Miguel; Máñez, Rafael; Rodríguez-Carmona, Ana; Peteiro, Javier; Martínez, Verónica; García Falcón, María Teresa; Doménech, Nieves (Elsevier, 2006-11-06)
      [Abstract] Background: Anti-Galα1-3Gal antibodies (anti-αGal) represent a significant fraction of natural antibodies and were implicated in several disease states, yet their origin and physiological significance remain ...
    • Specialized proresolving mediators protect against experimental autoimmune myocarditis by modulating Ca2+ handling and NRF2 activation 

      Val-Blasco, Almudena; Prieto, Patricia; Íñigo Jaén, Rafael; Gil-Fernández, Marta; Pajares, Marta; Doménech, Nieves; Terrón, Verónica; Tamayo, María; Jorge, Inmaculada; Vázquez, Jesús; Bueno-Sen, Andrea; Vallejo-Cremades, María Teresa; Pombo-Otero, Jorge; Sánchez-García, Sergio; Ruiz-Hurtado, Gema; Gómez, Ana María; Zaragoza, Carlos; Crespo-Leiro, María Generosa; López-Collado, Eduardo; Cuadrado, Antonio; Delgado, Carmen; Boscá, Lisardo; Fernández-Velasco, María (Elsevier, 2022-05-18)
      [Abstract] Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage ...
    • Survival impact of previous statin therapy in patients hospitalized with COVID-19 

      Barge-Caballero, Eduardo; Marcos-Rodríguez, Pedro J.; Doménech, Nieves; Bou, Germán; Cid-Fernández, Javier; Iglesias Reinoso, Raquel; López Vázquez, Paula; Muñiz, Javier; Vázquez-Rodríguez, José M.; Crespo-Leiro, María Generosa (Elsevier, 2022-12-07)
      [Abstract] tIntroduction: Statin therapy might have a beneficial prognostic effect in patients with COVID-19, givenits immunomodulative, anti-inflammatory and anti-atherosclerotic properties. Our purpose was to testthis ...
    • The addition of albumin improves Schwann cells viability in nerve cryopreservation 

      González Porto, Sara Alicia; Doménech, Nieves; González Rodríguez, Alba; Avellaneda Oviedo, Edgar Mauricio; Blanco García, Francisco J; Arufe, M.C.; Álvarez Jorge, Ángel; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Springer, 2018-04-26)
      [Abstract] The purpose of the current study was to establish a valid protocol for nerve cryopreservation, and to evaluate if the addition of albumin supposed any advantage in the procedure. We compared a traditional ...