Listar por autor "Ruiz-Romero, Cristina"

Mostrando ítems 1-18 de 18

    • A Clinical Model Including Protein Biomarkers Predicts Radiographic Knee Osteoarthritis: A Prospective Study Using Data From the Osteoarthritis Initiative 

      Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30)

    • A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis 

      Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)
      [Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ...

    • A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine 

      Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)
      [Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...

    • An atlas of the knee joint proteins and their role in osteoarthritis defined by literature mining 

      Paz-González, Rocío; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Quaranta, Patricia; Picchi, Florencia; Blanco García, Francico J; Ruiz-Romero, Cristina (Elsevier, 2023-08)
      [Abstract] Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common ...

    • Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers 

      Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)
      [Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ...

    • Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: a prospective study 

      Lourido Salas, Lucía María; Ruiz-Romero, Cristina; Picchi, Florencia; Diz-Rosales, Naomi; Vilaboa Galán, Sergio; Fernández-López, Carlos; Pinto-Tasende, José A.; Pérez-Pampin, Eva; Regueiro, Cristina; Mera-Varela, Antonio; González, Antonio; Hambardzumyan, Karen; Saevarsdottir, Saedis; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2020-06-30)
      [Abstract] Background: One-third of rheumatoid arthritis (RA) patients demonstrate no clinical improvement after receiving tumor necrosis factor inhibitors (TNFi). The presence of serum autoantibodies is a hallmark in RA ...

    • Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: a useful tool for precision medicine strategies 

      Ruiz-Romero, Cristina; Fernández-Puente, Patricia; González, Lucía; Illiano, Anna; Lourido, Lucía; Paz, Rocío; Quaranta, Patricia; Pérez-Pampín, Eva; González, Antonio; Blanco García, Francisco J; Calamia, Valentina (Frontiers, 2022-10-28)
      [Abstract] Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor ...

    • Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative 

      Camacho Encina, María; Balboa-Barreiro, Vanesa; Rego-Pérez, Ignacio; Picchi, Florencia; VanDuin, Jennifer; Qiu, Ji; Fuentes, Manuel; Oreiro, Natividad; LaBaer, Joshua; Ruiz-Romero, Cristina; Blanco García, Francisco J (BMJ, 2019-08-30)
      [Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ...

    • Discovery of circulating proteins associated to knee radiographic osteoarthritis 

      Lourido Salas, Lucía María; Ayoglu, Burcu; Fernández-Tajes, Juan; Oreiro, Natividad; Henjes, Frauke; Hellström, Cecilia; Schwenk, Jochen M.; Ruiz-Romero, Cristina; Nilsson, Peter; Blanco García, Francisco J (Nature, 2017-03-09)
      [Abstract] Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for ...

    • Exploring high-throughput immunoassays for biomarker validation in rheumatic diseases in the context of the human proteome project 

      Fuentes, Manuel; Ruiz-Romero, Cristina; Misiego, Sara; Juanes-Velasco, Pablo; Landeira-Viñuela, Alicia; Torres-Roda, Adrián; Lorenzo-Gil, Héctor; González-González, María; Hernández, Ángela P.; Lourido, Lucía; Sjöberg, Ronald; Pin, Elisa; Las Rivas, Javier de; Sánchez-Santos, José Manuel; Nilsson, Peter; Blanco García, Francisco J (ACS Publications, 2022-12-07)
      [Abstract] Rheumatic diseases are high prevalence pathologies with different etiology and evolution and low sensitivity in clinical diagnosis. Therefore, it is necessary to develop an early diagnosis method which allows ...

    • Identification of a Distinct Lipidomic Profile in the Osteoarthritic Synovial Membrane by Mass Spectrometry Imaging 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Ruiz-Romero, Cristina; Paine, Martin R.L.; Cañete, Juan D.; Heeren, Ron M.A.; Blanco García, Francisco J (Elsevier, 2021-05)
      [Abstract] Objective: Synovial inflammation is one of the most characteristic events in different types of arthritis, including Osteoarthritis (OA). Emerging evidence also suggests the involvement of lipids in the regulation ...

    • Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Eijkel, Gert; Calamia, Valentina; Fernández-Puente, Patricia; Paine, Martin R.L.; Ruiz-Romero, Cristina; Heeren, Ron M.A.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)
      [Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ...

    • Platelet-rich plasma in osteoarthritis treatment: review of current evidence 

      Gato Calvo, Lucía; Magalhaes, J.; Ruiz-Romero, Cristina; Blanco García, Francisco J; Burguera, Elena F. (Sage, 2019-02-19)
      [Abstract] Platelet-rich plasma (PRP) is defined as a volume of plasma with a platelet concentration higher than the average in peripheral blood. Many basic, preclinical and even clinical case studies and trials report ...

    • Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis 

      Blanco García, Francisco J; Camacho Encina, María; González-Rodríguez, Lucía; Rego-Pérez, Ignacio; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Picchi, Florencia; Silva-Díaz, María T.; Herrero, Marta; Martínez, Helena; Verges, Josep; Ruiz-Romero, Cristina; Calamia, Valentina (Sage, 2019-08-24)
      [Abstract] Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin ...

    • Prognostic model to predict the incidence of radiographic knee osteoarthritis 

      Paz-González, Rocío; Balboa-Barreiro, Vanesa; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco García, Francico J (BMJ, 2024-01-05)
      [Abstract] Objective: Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management of patients using preventative strategies. We develop and validate a prognostic model useful ...

    • Proteomic profiling of human menisci from mild joint degeneration and end-stage osteoarthritis versus healthy controls 

      Paz-González, Rocío; Turkiewicz, Aleksandra; Ali, Neserin; Ruiz-Romero, Cristina; Blanco García, Francisco J; Englund, Martin; Önnerfjord, Patrik (Elsevier, 2023-12)
      [Abstract] Objective. To gain new insight into the molecular changes of the meniscus by comparing the proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis (OA). Method. We obtained ...

    • Targeted Phospholipidomic Analysis of Synovial Fluid as a Tool for Osteoarthritis Deep Phenotyping 

      Rocha Loureda, Beatriz; Illiano, Anna; Calamia, Valentina; Pinto, Gabriella; Amoresano, Angela; Ruiz-Romero, Cristina; Blanco García, Francisco J (Elsevier, 2021-10-20)
      [Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ...

    • What did we learn from 'omics' studies in osteoarthritis 

      Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Blanco García, Francisco J (Wolters Kluwer, 2018-01-01)
      [Abstract] Purpose of review: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for ...