Listar por autor "Arufe, M.C."
Mostrando ítems 21-30 de 30
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Mesenchymal stromal cells for articular cartilage repair: preclinical studies
Fernández-Pernas, Pablo; Barrachina, Laura; Marquina, Maribel; Rodellar, C.; Arufe, M.C.; Costa, Cristina (AO Research Institute Davos (ARI), 2020-08-26)[Abstract] Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ... -
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
Mateos, Jesús; Fafián Labora, Juan Antonio; Morente-López, Miriam; Lesende-Rodríguez, Iván; Monserrat, Lorenzo; Ódena, María A.; Oliveira, Eliandre de; De-Toro, Javier; Arufe, M.C. (PLOS, 2018-10-31)[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ... -
Proteome analysis during chondrocyte differentiation in a new chondrogenesis model using human umbilical cord stroma mesenchymal stem cells
Fuente, Alexandre de la; Mateos, Jesús; Lesende-Rodríguez, Iván; Calamia, Valentina; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Arufe, M.C.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology, 2011-10-17)[Abstract] Umbilical cord stroma mesenchymal stem cells were differentiated toward chondrocyte-like cells using a new in vitro model that consists of the random formation of spheroids in a medium supplemented with fetal ... -
Proteomic applications in the study of human mesenchymal stem cells
Mateos, Jesús; Arufe, M.C.; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J (Multidisciplinary Digital Publishing Institute, 2014-02-07)Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ... -
Study of ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells
Alarcón-Veleiro, Carmen; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Vidal-Pampín, Andrea; Quindós-Varela, María; Al-Qatarneh, Thamer; Berrecoso, Germán; Vizoso-Vázquez, Ángel; Arufe, M.C.; Fafián Labora, Juan Antonio (MDPI, 2023-01-12)[Abstract] Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients ... -
The addition of albumin improves Schwann cells viability in nerve cryopreservation
González Porto, Sara Alicia; Doménech, Nieves; González Rodríguez, Alba; Avellaneda Oviedo, Edgar Mauricio; Blanco García, Francisco J; Arufe, M.C.; Álvarez Jorge, Ángel; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Springer, 2018-04-26)[Abstract] The purpose of the current study was to establish a valid protocol for nerve cryopreservation, and to evaluate if the addition of albumin supposed any advantage in the procedure. We compared a traditional ... -
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
Mato-Basalo, Rocío; Morente-López, Miriam; Arntz, O.J.; Van de Loo, F.J.; Fafián Labora, Juan Antonio; Arufe, M.C. (MDPI, 2021-03-25)[Abstract] Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these stem cells have been proposed as cell-free ... -
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
Morente-López, Miriam; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Silva-Fernández, Lucía; González-Rodríguez, Alba; De-Toro, Javier; Fafián Labora, Juan Antonio; Arufe, M.C. (Springer, 2022-10-20)[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ... -
Tratamiento de lesiones del cartílago articular con terapia celular
Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2008-11-13)[Resumen] Las lesiones del cartílago articular que no afectan a la integridad del hueso subcondral no se reparan espontáneamente. El carácter asintomático de estas lesiones propicia la progresiva degeneración articular y ... -
Umbilical Cord as a Mesenchymal Stem Cell Source for Treating Joint Pathologies
Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Baishideng, 2011-06-18)[Abstract] Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life. Regrettably, the regeneration of articular cartilage is a continuing challenge for biomedical ...