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Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
(Nature, 2015-05-21)
[Abstract] Article
Open Access
Published: 21 May 2015
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
Adrian Cortes, Sara L. Pulit, Paul J. ...
Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study
(BioMed Central, 2014-09-27)
[Abstract] INTRODUCTION:
Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...
Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis
(BMC, 2015-09-04)
[Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...
Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus
(BioMed Central, 2014-06-19)
[Abstract] INTRODUCTION:
We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was ...