Buscar
Mostrando ítems 1-10 de 11
Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
(Elsevier, 2006-05-05)
[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...
Is It Time for Epigenetics in Osteoarthritis?
(Wiley, 2014-05-16)
[Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ...
Mitochondrial haplogroups define two phenotypes of osteoarthritis
(Frontiers, 2012-05-11)
[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA).
Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...
An atlas of the knee joint proteins and their role in osteoarthritis defined by literature mining
(Elsevier, 2023-08)
[Abstract] Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common ...
Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint
(Springer, 2019-11-16)
[Abstract] Osteoarthritis (OA) is the most common form of arthritis and it is a leading cause of disability in the elderly. Its complete etiology is not known although there are several metabolic, genetic, epigenetic, and ...
Hydrogen sulfide and inflammatory joint diseases
(Bentham, 2017)
[Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...
Is osteoarthritis a mitochondrial disease?: what is the evidence
(Wolters Kluwer, 2022-01)
[Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease.
Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ...
Nitric Oxide Compounds Have Different Effects Profiles on Human Articular Chondrocyte Metabolism
(BioMed Central, 2013-09-11)
[Abstract] Introduction. The pathogenesis of osteoarthritis (OA) is characterized by the production of high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte-inducible nitric oxide synthase ...
Mitochondrial role on cellular apoptosis, autophagy, and senescence during osteoarthritis pathogenesis
(MDPI, 2024-06-04)
[Abstract] Authors have demonstrated that apoptosis activation is a pathway related to cartilage degradation characteristics of the OA process. Autophagy is an adaptive response to protect cells from various environmental ...
Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes
(Frontiers, 2021-06-15)
[Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...