Mostrando ítems 1-10 de 14
Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes
(Frontiers, 2021-06-15)
[Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...
Subcutaneous Tanezumab for Osteoarthritis: Is the Early Improvement in Pain and Function Meaningful and Sustained?
(Wiley, 2021-03-16)
[Abstract] Background: To evaluate if early improvements in pain and function with subcuta-neous tanezumab are meaningful and sustained over 24 weeks.
Methods: Patients with moderate- to- severe osteoarthritis (hip or ...
Mitochondrial DNA Impact on Joint Damaged Process in a Conplastic Mouse Model After Being Surgically Induced With Osteoarthritis
(Nature, 2021-04-27)
[Abstract] It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced ...
Identification of a Distinct Lipidomic Profile in the Osteoarthritic Synovial Membrane by Mass Spectrometry Imaging
(Elsevier, 2021-05)
[Abstract] Objective: Synovial inflammation is one of the most characteristic events in different types of arthritis, including Osteoarthritis (OA). Emerging evidence also suggests the involvement of lipids in the regulation ...
PROCOAC (PROspective COhort of A Coruña) description: Spanish prospective cohort to study osteoarthritis
(Elsevier, 2021-05-03)
[Abstract] Introduction and objective: The use of well characterized osteoarthritis (OA) cohorts is mandatory for the study and knowledge of this disease. Currently, there is no prospective cohort in this pathology in ...
Are Musculoskeletal Conditions Neglected in National Health Surveys?
(Oxford University Press, 2021-01-26)
[Abstract] Objective: To describe the proportion of national health surveys that contain questions on the prevalence and consequences of musculoskeletal conditions.
Methods: We used a comprehensive search strategy to ...
One-year, efficacy and safety open label study, with a single injection of a new hyaluronan for knee OA: the SOYA trial
(DovePress, 2021-07-21)
[Abstract] Purpose. To assess the efficacy and safety of a single injection of a new formulation of hyaluronic acid (MPS-HA2%) in patients with symptomatic knee osteoarthritis after 12 months’ follow-up.
Patients and ...
Prevalence of Symptomatic Axial Osteoarthritis Phenotypes in Spain and Associated Socio-Demographic, Anthropometric, and Lifestyle Variables
(Springer, 2021-11-10)
[Abstract] Objective. Axial osteoarthritis (OA) is a common cause of back and neck pain, however, few studies have examined its prevalence. The aim was to estimate the prevalence and the characteristics of symptomatic axial ...
Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis
(MDPI, 2021-06-16)
[Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release ...
Targeted Phospholipidomic Analysis of Synovial Fluid as a Tool for Osteoarthritis Deep Phenotyping
(Elsevier, 2021-10-20)
[Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ...