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Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis
(MDPI, 2020-10-08)
[Abstract]
Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...
Mitochondrial DNA Impact on Joint Damaged Process in a Conplastic Mouse Model After Being Surgically Induced With Osteoarthritis
(Nature, 2021-04-27)
[Abstract] It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced ...
Study of Fucoidans as Natural Biomolecules for Therapeutical Applications in Osteoarthritis
(Elsevier, 2021-01-26)
[Abstract]
Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules ...
mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model
(Impact Journals, 2022-07-02)
[Abstract] Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A ...
Reduced Levels of H₂S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction
(MDPI, 2022-03-25)
[Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...
In vitro study of the therapeutic potential of brown crude fucoidans in osteoarthritis treatment
(MDPI, 2022-11-17)
[Abstract] Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a ...
Antifibrotic Effect of Brown Algae-Derived Fucoidans on Osteoarthritic Fibroblast-Like Synoviocytes
(Elsevier, 2022-01-12)
[Abstract] Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as ...